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Non Operative Breast Pathology: lobular neoplasia
  1. Jorge S Reis-Filho (jorgerf{at}
  1. The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, United Kingdom
    1. Sarah E Pinder (sep43{at}
    1. Addenbrooke's NHS Trust, United Kingdom


      Lobular neoplasia is a relatively uncommon lesion, which is frequently diagnosed in biopsies taken for other reasons. Although the histological features of this lesion are well known, its biological significance as a 'risk indicator' or 'breast cancer precursor' has been a matter of debate. This review provides an update on recent clinico-pathological and molecular data on lobular neoplasia and how these have changed the way these lesions are perceived and, most importantly, managed. Furthermore, the current recommendations for the management of lobular neoplasia diagnosed on core needle biopsies proposed in the National Health Service Breast Cancer Screening guidelines are discussed.

      • E-cadherin
      • atypical lobular hyperplasia
      • beta-catenin
      • lobular carcinoma in situ
      • pleomorphic lobular carcinoma

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