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Problems of basing patient recruitment for primary care studies on routine laboratory submissions
  1. Cliodna A M McNulty (cliodna.mcnulty{at}hpa.org.uk)
  1. Health Protection Agency, United Kingdom
    1. Michael Thomas (mikethomas{at}doctors.org.uk)
    1. University of Aberdeen and Bell Lane Surgery, United Kingdom
      1. Rhiannon John (rhiannon.john{at}north-bristol.swest.nhs.uk)
      1. Southmead Hospital, United Kingdom
        1. Andrew Lovering (lovering_a{at}southmead.swest.nhs.uk)
        1. Southmead Hospital, United Kingdom
          1. Deirdre Lewis (deirdre.lewis{at}hpa.org.uk)
          1. Health Protection Agency, United Kingdom
            1. Alasdair MacGowan (macgowan_a{at}southmead.swest.nhs.uk)
            1. Southmead Hospital, United Kingdom

              Abstract

              Aims: Using routine urine submission rates for estimation of patient enrolment in primary care studies of acute urinary symptoms may over-estimate patient recruitment rate. We compared the rates of submission of urines and significant bacteriuria from patients presenting with acute urinary symptoms in study general practices to routine microbiology laboratory urines.

              Patients and methods: Routine laboratory urine submissions were determined by counting all MSU specimens submitted to the laboratory from 12 large GP practices served by Gloucester and Southmead microbiology departments over two years (2000-2002). Urine specimens were requested from all patients with acute urinary symptoms referred at research nurse practice visits over the same time period. The annual study urine submission was calculated using the ratio of the number of nurse practice visits to the annual number of possible consulting sessions. Significant bacteriuria was defined as a urine growing a single organism reported as >105 colony forming units/ml. Rates per 1000 patients were calculated using practice population data.

              Results: The urine submission rate from study patients with acute urinary symptoms was one-third the routine urine submission rate from the same practices. The significant bacteriuria rate attained from the study was less than half the routine significant bacteriuria rate.

              Conclusion: Two-thirds of routine urine samples submitted by GPs are probably not for the investigation of acute urinary symptoms. Basing consultation sample size power calculations for primary care studies or sentinel practice-based surveillance in UTI on routine laboratory submissions is unreliable and will lead to significant overestimation of recruitment rate.

              • Antibiotic resistance surveillance
              • Microbiology laboratory
              • Patient recruitment
              • Primary care

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