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A growing burden: the pathogenesis, investigation and management of non-alcoholic fatty liver disease
  1. Paul Riley (paul.riley{at}
  1. University Hospital Lewisham, United Kingdom
    1. John O'Donohue (john.o'donohue{at}
    1. University Hospital Lewisham, United Kingdom
      1. Martin Crook (martin.crook{at}
      1. University Hospital Lewisham, United Kingdom


        Nonalcoholic Fatty Liver Disease (NAFLD) is the most common hepatic disorder in western countries, and its incidence is increasing. In this review we outline the significant health burden posed by NAFLD and discuss what is presently known about its pathogenesis, including the roles of the metabolic syndrome, obesity, insulin resistance, hepatic steatosis, reactive oxygen species, inflammatory cytokines and adipocytokines. We look at the way in which NAFLD is clinically diagnosed and identify areas of uncertainty surrounding its investigation, before discussing the relative merits of the limited treatment options available and looking ahead to potential therapeutic strategies for the future.

        • Insulin Resistance
        • Nonalcoholic Fatty Liver Disease
        • Nonalcoholic Steatohepatitis
        • Obesity
        • Weight Loss

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