Introduction: Immune factors influencing progression of cervical intraepithelial neoplasia (CIN) cancer remain poorly defined.
Aim: This study investigates the expression of RANTES, MIP-1 α, COX-1, COX-2, STAT-3, TGF- RI, IL-10R, TNFα-RII and TLR-4 in the cervical immune response in the HIV/HPV co-infected women.
Methods: Cervical biopsies of 36 patients were assayed by immunohistochemistry, and the VENTANA System was used for HIV-nef detection.
Results: Cervices from HIV+ patients showed nef in cells mainly around blood vessels, showing a decreased expression of all but IL-10R and STAT-3 while RANTES (P= 0.02) was highly expressed in comparison to controls. COX-1 was decreased in the HIV/HPV (P= 0.017) and HPV infected patients (P= 0.015) compared to controls.
Conclusion: We suggest that RANTES in HIV/HPV co-infection could influence the development of CIN and progression to cervical cancer.
- immune factors