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Immune factors involved in the cervical immune response in the HIV/HPV co-infection
  1. Alcina Frederica Nicol (nicol{at}ioc.fiocruz.br)
  1. Immupathology laboratory - IOC - FIOCRUZ, Brazil
    1. Arthur S Estevez (arthursalomao{at}gmail.com)
    1. Laboratory of Immunopathology– Department of biochemystry and Molecular Biology- FIOCRUZ, Brazil
      1. Gerard J Nuovo (nuovo-1{at}medctr.osu.edu)
      1. Department of Pathology, The Ohio State University Medical Center -Columbus-OH, United States
        1. Beatriz Grinsztejn (gbeatriz{at}unisys.com.br)
        1. Department of Infectious Disease of Evandro Chagas Clinical Research Institute- Fiocruz, Brazil
          1. Aparecida Tristão (atristao{at}unisys.com.br)
          1. Fernandes Figueira Institute, Department of Pathology, Oswaldo Cruz Foundation, RJ, Brazil, Brazil
            1. Fabio B Russomano (frussomano{at}superig.com.br)
            1. Fernandes Figueira Institute, Department of Pathology, Oswaldo Cruz Foundation, RJ, Brazil, Brazil
              1. José R Lapa e Silva (jrlapa.ntg{at}terra.com.br)
              1. Multidisciplinary Laboratory, Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro, Brazil
                1. Marcia P DeOliveira (marciapo{at}ioc.fiocruz.br)
                1. Laboratory of Immunopathology– Department of biochemystry and Molecular Biology- Fiocruz, Brazil
                  1. Claude Pirmez (pirmez{at}ioc.fiocruz.br)
                  1. - Laboratory of Immunopathology– Department of biochemystry and Molecular Biology- FIOCRUZ, Brazil

                    Abstract

                    Introduction: Immune factors influencing progression of cervical intraepithelial neoplasia (CIN) cancer remain poorly defined.

                    Aim: This study investigates the expression of RANTES, MIP-1 α, COX-1, COX-2, STAT-3, TGF- RI, IL-10R, TNFα-RII and TLR-4 in the cervical immune response in the HIV/HPV co-infected women.

                    Methods: Cervical biopsies of 36 patients were assayed by immunohistochemistry, and the VENTANA System was used for HIV-nef detection.

                    Results: Cervices from HIV+ patients showed nef in cells mainly around blood vessels, showing a decreased expression of all but IL-10R and STAT-3 while RANTES (P= 0.02) was highly expressed in comparison to controls. COX-1 was decreased in the HIV/HPV (P= 0.017) and HPV infected patients (P= 0.015) compared to controls.

                    Conclusion: We suggest that RANTES in HIV/HPV co-infection could influence the development of CIN and progression to cervical cancer.

                    • Cervix
                    • Cyclooxygenases
                    • HIV/HPV
                    • RANTES
                    • immune factors

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