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The antinuclear antibody is associated with a more advanced fibrosis and lower RNA levels of hepatitis C virus in chronic hepatitis C patients
  1. Ming-Yen Hsieh (d850082{at}gmail.com)
  1. Kaohsiung Medical University Hospital, Taiwan
    1. Chia-Yen Dai (d820195{at}gmail.com)
    1. Kaohsiung Medical University Hospital, Taiwan
      1. Li-Po Lee (lipolee{at}kmu.edu.tw)
      1. Kaohsiung Medical University Hospital, Taiwan
        1. Jee-Fu Huang (jeefuhuang{at}yahoo.com.tw)
        1. Kaohsiung Medical University Hospital, Taiwan
          1. Wen-Chan Tsai (d10153{at}ms14.hinet.net)
          1. Kaohsiung Medical University Hospital, Taiwan
            1. Nai-Jen Hou (hnr58815{at}ms13.hinet.net)
            1. Kaohsiung Medical University Hospital, Taiwan
              1. Zu-Yau Lin (zuyali{at}kmu.edu.tw)
              1. Kaohsiung Medical University Hospital, Taiwan
                1. Shinn-Cherng Chen (chshch{at}kmu.edu.tw)
                1. Kaohsiung Medical University Hospital, Taiwan
                  1. Liang-Yen Wang (liyewa{at}kmu.edu.tw)
                  1. Kaohsiung Medical University Hospital, Taiwan
                    1. Wen-Yu Chang (weyuch{at}kmu.edu.tw)
                    1. Kaohsiung Medical University Hospital, Taiwan
                      1. Wan-Long Chuang (waloch{at}kmu.edu.tw)
                      1. Kaohsiung Medical University Hospital, Taiwan
                        1. Ming-Lung Yu (d820195{at}kmu.edu.tw)
                        1. Kaohsiung Medical University Hospital, Taiwan

                          Abstract

                          Aims: Positive serum antinuclear antibody (ANA) emerges in some proportion of patients with chronic hepatitis C virus (HCV) infection. This study aimed to evaluate the prevalence of ANA in chronic hepatitis C (CHC) patients and to elucidate its clinical implication in the virologic and histologic characteristics.

                          Methods: Total 614 CHC patients were enrolled in this prospective, hospital-based study. The serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ANA, HCV genotypes, HCV RNA levels and histologic activity index (HAI) scores for liver histopathology were determined.

                          Results: The prevalence of positive ANA (titer > 1:40) was 35.0%. Women had a significantly higher prevalence than men (41.2% vs. 31.0%, P = 0.012). Patients with positive ANA were significantly older (mean 53.7 ± 10.5 vs. 49.7 ¡&Oacute 11.3 yrs, P < 0.001) and had higher mean ALT levels (186.9 ± 178.8 vs. 155.50 ± 113.5 IU/L, P < 0.001) and lower mean HCV RNA levels (5.2 ± 0.9 vs. 5.4 ± 1.0 log IU/mL, P = 0.048) than those without. Amongst 447 patients receiving liver biopsy, those with positive ANA significantly had a higher mean fibrosis score (2.0 ± 1.3 vs. 1.5 ± 1.1, P<0.001) and a higher frequency of F3-4 (69/187, 36.9% vs. 50/260, 19.2%, P<0.001) than those without. Multivariate logistic regression analyses showed that advanced fibrosis, lower HCV RNA levels, and age were significant factors related to positive ANA.

                          Conclusion: ANA is associated with a more advanced liver fibrosis and lower serum HCV RNA levels in CHC patients.

                          • HCV RNA
                          • HCV RNA level
                          • antinuclear antibody
                          • chronic hepatitis C
                          • liver fibrosis

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