Article Text

other Versions

Non Operative Breast Pathology: An overview of assessment of prognostic and predictive factors in breast cancer needle core biopsy specimens
  1. Emad Rakha
  1. University of Nottigham, United Kingdom
    1. Ian O Ellis (ian.ellis{at}
    1. University of Nottigham, United Kingdom


      Needle core biopsy (NCB), as part of triple assessment for preoperative evaluation and diagnosis of breast cancer, is now considered as an established, highly accurate method for diagnosing breast cancer that has replaced either fine needle aspiration cytology or excisional biopsy as the initial diagnostic biopsy procedures in many institutions. Aside for its primary role in establishing an accurate histologic diagnosis, NCB can potentially provide important additional pathological prognostic information which may be of direct clinical value in certain situations such as patients being considered for preoperative (neoadjuvant) therapy. With this background in mind we briefly review the current role of needle core biopsy in breast cancer diagnosis and then concentrate this review on the usefulness and issues relating to use of this technique to providing accurate, reliable and clinically relevant preoperative prognostic, and predictive information in breast cancer patients.

      • Breast cancer
      • core needle biopsy
      • predictive factors
      • prognostic factors

      Statistics from

      Request permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.