Article Text

other Versions

PDF
Frequent nuclear expression of β-catenin protein but rare β-catenin mutation in pulmonary sclerosing hemangioma
  1. Po-Min Chiang (omicron{at}mail2000.com.tw)
  1. National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan
    1. Ray-Hwang Yuan (rhyuan{at}hotmail.com)
    1. National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan
      1. Hey-Chi Hsu (heychi{at}ntu.edu.tw)
      1. National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan
        1. Tsui-Lien Mao
        1. National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan
          1. Rey-Heng Hu
          1. National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan
            1. Po-Lin Lai (polin{at}ntuh.gov.tw)
            1. National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan
              1. Yung-Ming Jeng (d83409009{at}ntu.edu.tw)
              1. National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taiwan

                Abstract

                Background: Pulmonary sclerosing hemangioma (PSH) is an uncommon tumor that composed of glandular/papillary lining cells and polygonal cells. Even though the biologic behavior of this tumor has been investigated, the molecular pathogenesis of PSH was still unknown.

                Aims: To characterize the role of Wnt/β-catenin pathway in the genesis of PSH.

                Methods: 37 PSH samples were investigated by immunohistochemical detection of β-catenin protein and direct sequencing of exon 3 of β-catenin gene.

                Results: Nuclear expression of β-catenin were found in the lining component of 23 tumors (62%) and in the polygonal component of 11 tumors (30%). The expression of β-catenin was stronger in lining component, but weaker in polygonal component. Intrestingly, all the tumors with expression of β-catenin in the polygonal component also expressed β -catenin in the lining component. But mutation of exon 3 of β-catenin gene was detected in only one tumor that expressed nuclear β-catenin in both lining and polygonal components.

                Conclusions: Wnt/β-catenin pathway was involved in genesis of PSH , but mutation of exon 3 of -βcatenin gene rarely contributed to the activation of Wnt/β-catenin pathway in PSH.

                • gene mutation
                • pulmonary sclerosing hemangioma
                • £]-catenin

                Statistics from Altmetric.com

                Request permissions

                If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.