Article Text

other Versions

PDF
Enterovirus infection of the stomach in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME)
  1. Jonathan R Kerr (jkerr{at}sgul.ac.uk)
  1. St George's University of London, United Kingdom

    Abstract

    Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME) is a disease characterised by severe and debilitating fatigue, sleep abnormalities, impaired memory and concentration, and musculoskeletal pain. In the Western world, the population prevalence is estimated to be of the order of 0.5%. Research studies have identified various features relevant to the pathogenesis of CFS/ME such as viral infection, immune abnormalities and immune activation, exposure to toxins, chemicals and pesticides, stress, hypotension, lymphocyte abnormalities and neuroendocrine dysfunction. However, the precise underlying disease mechanisms and means by which these abnormalities inter-relate in CFS/ME patients, remain to be clarified. Various viruses have been shown to play a triggering or perpetuating role, or both, in this complex disease. Microbes which have been shown to trigger CFS/ME include enteroviruses, Epstein-Barr virus, Chlamydia pneumoniae, parvovirus B19, Coxiella burnetii, Borna disease virus, Varicella Zoster virus, cytomegalovirus, and human herpesvirus type 6 (HHV-6). Chronic microbial infections which have been documented in CFS/ME patients include Coxiella burnetii, parvovirus B19, Chlamydia pneumoniae, hepatitis C, enteroviruses and human retroviruses. Virus reactivations in CFS/ME include Varicella-Zoster virus, Herpes Simplex virus (HSV) (increased frequency of cold sores) and EBV.

    • Chronic Fatigue Syndrome
    • Myalgic Encephalomyelitis
    • enterovirus
    • stomach
    • virus

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.