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Comparison of examination of the entire uterine cervix with routine sampling in hysterectomy specimens from women with endometrial cancer
  1. Anitha Nayar (anitha.nayar{at}ghnt.nhs.uk)
  1. Gateshead Health NHS Foundation Trust, United Kingdom
    1. Paul A Cross (paul.cross{at}ghnt.nhs.uk)
    1. Gateshead Health NHS Foundation Trust, United Kingdom
      1. Judith Bulmer
      1. Royal Victoria Infirmary Newcastle Upon Tyne, United Kingdom
        1. Suha Deen
        1. Nottingham University Hospital, United Kingdom
          1. Amira El-Sherif
          1. Royal Victoria Infirmary Newcastle Upon Tyne, United Kingdom

            Abstract

            Aim: Cervical involvement by endometrial cancer alters the FIGO stage and determines clinical management but there are no accepted guidelines for cervical sampling of these cases. The aim of this study was to assess whether sampling more than two "routine" blocks of the cervix (anterior and posterior) alters the pathological staging of hysterectomy specimens for endometrial cancer. Methods: Histological involvement of the cervix was prospectively compared in hysterectomies performed for proven endometrial cancer (n=61). Specimens had two "routine" blocks taken from anterior and posterior cervix; all of the remaining cervix was also processed for histological assessment. Results: 61 cases of endometrial cancer had the entire uterine cervix processed. These included 54 cases of endometrioid adenocarcinoma and 7 special types. Twelve cases had cervical involvement (Stage 2A or 2B), and seven cases were Stage 3A or above, of which three also had cervical involvement. In none of the 61 cases did the additional cervical blocks (n=544) taken alter the staging made on the "routine" blocks. Conclusion: Sampling of two blocks from the cervix appears sufficient for histological staging of endometrial cancer in hysterectomy specimens.

            • FIGO
            • cervical involvement
            • endometrial cancer
            • endometrial cancer staging

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