Article Text

other Versions

Immunohistochemical markers as predictive tools for breast cancer
  1. Rosemary A Walker (raw14{at}
  1. Breast Cancer Research Unit, University of Leicester, United Kingdom


    Breast cancer is the predominant malignancy where oncologists use predictive markers clinically to select treatment options, with steroid receptors being used for many years. Immunohistochemistry has taken over as the major assay method used for assessing markers. Despite its extensive use there are still issues around tissue fixation, methodology, interpretation and quantification. Although many markers have been evaluated, oestrogen receptor remains the most reliable and best example of a predictor of treatment response. It is of major importance clinically that those undertaking interpretation of predictive markers understand the technical pitfalls and are aware of how expression of a particular marker relates to breast cancer pathology. A false negative or a false positive result will impact on patient management.

    • HER2
    • breast cancer
    • immunohistochemistry
    • interpretation
    • oestrogen receptor

    Statistics from

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.