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Genetically determined susceptibility to mycobacterial infection
  1. Smita Y Patel
  1. Addenbooke’s Hospital, Cambridge, United Kingdom
    1. Rainer Doffinger
    1. Addenbooke’s Hospital, Cambridge, United Kingdom
      1. Gabriella Barcenas-Morales
      1. Universidad Nacional Autonoma de Mexico, Mexico
        1. Dinakantha Kumararatne (dsk22{at}cam.ac.uk)
        1. Addenbrooke's Hospital, Cambridge, UK, United Kingdom

          Abstract

          This review will focus on patients with genetic defects predisposing to infections with poorly pathogenic mycobacteria [Bacillus Calmette-Guerin and environmental Non-Tuberculous Mycobacteria (NTM)] as well as Salmonella species. Mycobacteria and Salmonella are facultative intracellular pathogens capable of surviving and multiplying within mononuclear phagocytes. Host defense against these pathogens depends on the action of cell-mediated immunity (CMI), effected by interactions between T cells and macrophages. The principal effector mechanism responsible immunity against these pathogens is the activation of infected macrophages by type 1 cytokines, particularly interferon-γ (IFN-γ) and Tumor necrosis factor alpha (TNF-α)[1].

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