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Cytologic distinction between high-risk and low-risk human papillomavirus (HPV) infections in SurePath™ liquid-based cell preparations
  1. Nelson K.S Wong
  1. Compuscreen medical diagnostic Centre and The Hong Kong Polytechnic University, China
    1. Idy F.Y. Ng
    1. Compuscreen medical diagnostic Centre, China
      1. Gina Leung (gina.leung{at}
      1. The Hong Kong Polytechnic University, China


        Aims: To investigate the correlation of various diagnostic cytologic features demonstrated in SurePath liquid-based cell preparations with the infection of high-risk human papillomavirus (HPV).

        Methods: A case-control study design. 510 cases of SurePath specimens that had been tested for HPV DNA by Hybrid Capture 2 assay were retrieved and re-examined for ten cytologic features. Distribution of these features in high- and low-risk HPV types was compared and risk statistics were estimated. Effects of cervicitis on the manifestation of HPV cytologic changes were adjusted by means of logistic regression.

        Results: Cytologic features of nuclear hyperchromasia, multinucleation and atypical metaplastic cells were predominantly noted in high-risk HPV infection in the category of ASCUS/LSIL. The odds ratios of these three features were 6 to 12 times higher in high-risk than low-risk HPV infection.

        Conclusions: Some diagnostic cytologic features can be used as markers in Pap smear screening for assessing the types of HPV infection.

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