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Hypertrophic Cardiomyopathy: Current understanding and treatment objectives
  1. Gursharan S Soor
  1. Department of Pathology, Toronto General Hospital/ University Health Network, Toronto, Canada
    1. Adriana Luk (adriana.luk{at}utoronto.ca)
    1. Department of Medicine, Toronto General Hospital/ University Health Network, Toronto, Canada
      1. Eric Ahn
      1. Department of Pathology, Toronto General Hospital/ University Health Network, Toronto, Canada
        1. Jonathan R Abraham
        1. Department of Pathology, Toronto General Hospital/ University Health Network, Toronto, Canada
          1. Anna Woo
          1. Hypertrophic Cardiomyopathy Program, Division of Cardiology, Toronto General Hospital, University o, Canada
            1. Anthony Ralph-Edwards
            1. Division of Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
              1. Jagdish Butany (jagdish.butany{at}uhn.on.ca)
              1. Department of Pathology, Toronto General Hospital/ University Health Network, Toronto, Canada

                Abstract

                The understanding of hypertrophic cardiomyopathy (HCM) has changed dramatically over the last few decades, where it is now understood to be caused by a mutation in one of several cardiac sarcomeric genes. Due to complications such as outflow tract obstruction, diastolic dysfunction, arrhythmias, stroke, infective endocarditis (IE), and sudden cardiac death (SCD), appropriate and early identification of these patients is imperative. This review attempts to summarize the current state of knowledge on HCM, and provide insight of the appropriate investigations needed in patients with HCM. It also outlines treatment strategies for these patients. Much remains unknown about this complex and intriguing disease, and continued research in identifying the genetic basis of HCM, along with the assessment of therapeutic strategies, will help optimize patient care.

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