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Anaplastic nephroblastomas express transketolase-like enzyme 1
  1. Hue-Tsi Wu (hue-tsi.wu{at}uct.ac.za)
  1. University of Cape Town, South Africa
    1. Nafiesa Allie (nafiesa.allie{at}uct.ac.za)
    1. University of Cape Town, South Africa
      1. Landon Myer (landon.myer{at}uct.ac.za)
      1. University of Cape Town, South Africa
        1. Dhirendra Govender (dhiren.govender{at}uct.ac.za)
        1. University of Cape Town, South Africa

          Abstract

          Aim: Transketolase-like enzyme 1 (TKTL1) is a glycolytic enzyme found to be upregulated in several tumours and associated with tumour progression. Nephroblastoma is the commonest paediatric renal malignancy and has a good prognosis except for those with anaplasia. The expression of nephroblastoma and TKTL1 has not been studied before and we embark on a study to compare the immunoexpression of TKTL1 in anaplastic and non-anaplastic nephroblastomas.

          Methods: Twenty eight patients who had nephrectomies for nephroblastomas were studied. Archival formalin-fixed, paraffin wax-embedded tissue sections were stained with monoclonal TKTL1 antibody.

          Results: Six of the 15 anaplastic nephroblastomas showed staining in 80-100% of the tumour (p=0.36). None of the thirteen non-anaplastic nephroblastomas showed TKTL1 staining in >80% of the tumour.

          Conclusion: TKTL1 expression is associated with the presence of anaplasia and may be a mechanism via which anaplastic tumour cells thrive under different conditions. Glycolytic inhibitors may play a role in anaplastic nephroblastomas.

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