Article Text

other Versions

PDF
Relationship between Vitamin D, calcium and PTH in Cape Town
  1. David Haarburger (david.haarburger{at}uct.ac.za)
  1. Groote Schuur Hospital, University of Cape Town, South Africa
    1. Mariza Hoffmann (mariza{at}sun.ac.za)
    1. Tygerberg Hospital, South Africa
      1. Rajiv Erasmus (rte{at}sun.ac.za)
      1. University of Stellenbosch, South Africa
        1. Tahir Pillay (profts.pillay{at}uct.ac.za)
        1. University of Cape Town, South Africa

          Abstract

          Aim: The aim of this study was to test the hypothesis that Vitamin D deficiency is associated with abnormal Calcium and PTH levels.

          Methods: Vitamin D requests at a tertiary hospital in South Africa over 2 years were retrospectively analysed along with calcium and PTH levels.

          Results: Only when 25(OH)D level dropped below 25nmol/l, was there a significant rise in PTH. A subnormal 25(OH)D level was also not always related to hypocalcaemia as more than half of patients with their 25(OH)D level below 25nmol/l had calcium levels in the reference range. However, all patients with calcium levels below 1.8mmol/l were shown to have Vitamin D insufficiency.

          Conclusion: Hypovitaminosis D may co-exist with a blunted PTH response. Therefore, assumptions about vitamin D status should not be made based on PTH and calcium values. 25(OH)D measurements should be requested when vitamin D deficiency is clinically suspected, irrespective of biochemical results.

          Statistics from Altmetric.com

          Request permissions

          If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.