Article Text

other Versions

Hyaline vascular Castleman disease relapsing as T cell rich B cell lymphoma with paraneoplastic pemphigus
  1. Meeta Singh,
  2. Vijay Saroha,
  3. Parul Gupta,
  4. Praveen Gupta,
  5. Nita Khurana,
  6. Tejinder Singh
  1. Department of Pathology and Medicine, Maulana Azad Medical College, New Delhi, India
  1. Correspondence to Dr Meeta Singh, Room No 62, Maulana Azad Medical College, New Delhi-110002, India; meetamamc{at}

Statistics from

A 32-year-old woman presented with mild fever and solitary discrete cervical lymph node (5 cm) for 2 years. The excision biopsy showed preserved lymph-node architecture with prominent onion skinning (figure 1) and hyalinised blood vessels in the germinal centres (figure 1, inset). The patient was investigated thoroughly for lymph nodes else where, but no lymph nodes could be detected. The overall picture was suggestive of localised Castleman disease (LCD), hyaline vascular type. The HIV, HHV-8 and Epstein Barr Virus serology was negative.

Figure 1

Hyaline vascular Castleman disease with prominent onion skinning and hyalinised blood vessels (H& E staining, 100×; inset: 400×).

The patient returned 5 years later with abdominal distension, weight loss, cervical and inguinal lymphadenopathy, hepatoslenomegaly and vescicobullous skin rashes for 3 months. CT and MRI revealed multiple cervical, retroperitoneal and mediastinal lymph nodes (figure 2). …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.