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Lymph node distribution and pattern of metastases in the mesorectum following total mesorectal excision using the modified fat clearing technique
  1. Yun-Feng Yao1,
  2. Lin Wang1,
  3. Yi-Qiang Liu2,
  4. Ji-You Li2,
  5. Jin Gu1
  1. 1Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Colorectal Surgery, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, PR China
  2. 2Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, PR China
  1. Correspondence to Professor Jin Gu, Peking University School of Oncology & Beijing Cancer Hospital, Department of Colorectal Surgery, Peking University, Beijing, 52 Fu Cheng Lu, PR China; zjguj{at}hsc.pku.edu.cn

Abstract

Aim To define the distribution, size, location and metastasis of lymph nodes (LNs) within the mesorectum from rectal cancer specimens following total mesorectal excision (TME) surgery without neoadjuvant therapy.

Methods Specimens from 60 patients who underwent TME were treated with modified fat clearing solution to retrieve LNs. The mesorectum was divided into right lateral, anterior, posterior and left lateral sides, which were further subdivided into three levels (upper, middle and lower).

Results 1436 LNs were harvested, including 985 small LNs (<5 mm in size). The number of LNs from the anterior, posterior and bilateral mesorectum was 125 (8.7%), 696 (48.5%) and 615 (42.8%), respectively. In the longitudinal axis, the difference in distribution at the three levels was not significant. 200 LN metastases (mLNs) were detected in 33 patients. 48% (96/200) of these were small LNs. More mLNs, especially small LNs, were shown in the more advanced T stage patients. The mLN metastasis rate was not influenced by tumour level.

Conclusion Small LN detection increased the accuracy of N staging by 20% in this study. The incidence of metastasis was the same among the anterior, bilateral and posterior areas of the mesorectum. An increased incidence of mLN metastasis in small LNs was associated with more advanced T staging. mLN metastasis rates in both middle and low rectal cancer were higher in the distal mesorectum than that in the proximal mesorectum. LN number and density were not consistent with spread of the primary tumour. Distal mLNs were found in 35% of cases of both middle and distal rectal cancer, implying a need for TME in both.

  • Colorectal cancer
  • gall bladder
  • oncogenes
  • P53
  • pancreas
  • rectal cancer
  • lymph node pathology
  • surgery

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Footnotes

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The protocol was reviewed and approved by the Institutional Review Board of Beijing Cancer Hospital & Institute.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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