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Paratesticular mesothelioma is a rare tumour, representing only 0.3–5% of all mesotheliomas; approximately 223 cases have been described to date.1 Morphologically, most paratesticular mesotheliomas are epithelial, or mixed epithelial and sarcomatoid; with papillary, tubulopapillary or solid architectural patterns.2 3 Papillary mesotheliomas can be difficult to distinguish from papillary serous carcinoma on morphological grounds alone and usually require immunohistochemical and ultrastructural studies. Mesotheliomas are typically positive for calretinin, CK5/6, D2-40, vimentin and thrombomodulin but negative for BerEp4, LeuM1, CEA and CK20; whereas carcinomas typically show the reverse pattern.1 3–5 Rare BerEp4 and LeuM1 positivity is well documented in mesothelioma, although the staining is usually weak and …
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