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Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa
  1. Jan Bornschein1,
  2. Kinga Tóth2,
  3. Michael Selgrad1,
  4. Doerthe Kuester3,
  5. Thomas Wex1,4,
  6. Béla Molnár2,5,
  7. Zsolt Tulassay2,5,
  8. Peter Malfertheiner1
  1. 1Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke University, Magdeburg, Germany
  2. 22nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
  3. 3Department of Pathology, Otto-v.-Guericke University, Magdeburg, Germany
  4. 4Department of Molecular Genetics, Center for Laboratory Medicine, Microbiology and Infectious Diseases, Magdeburg, Germany
  5. 5Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
  1. Correspondence to Dr Peter Malfertheiner, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke University, Leipziger Str. 44, Magdeburg 39120, Germany; peter.malfertheiner{at}med.ovgu.de

Abstract

The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of 48 gastric cancer patients with 30 healthy controls. There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumour-distant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01). SOX2 was downregulated in tumour tissue compared to controls, whereas tumour-adjacent and tumour-distant mucosa showed intermediate SOX2 expression. Laurén type and Helicobacter pylori infection had no significant impact on expression of the transcription factors. Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.

  • GASTRIC CANCER
  • GASTRITIS
  • H PYLORI
  • HELICOBACTER PYLORI
  • MOLECULAR ONCOLOGY

https://doi.org/10.1136/jclinpath-2013-201448

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