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Aggressive variants of follicular cell derived thyroid carcinoma; the so called ‘Real Thyroid Carcinomas’
  1. Zubair Baloch1,
  2. Virginia A LiVolsi2,
  3. Rashmi Tondon2
  1. 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  2. 2Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  1. Correspondence to Dr Zubair Baloch, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA; baloch{at}mail.med.upenn.edu

Abstract

The pathological diagnoses and classification schemes for thyroid carcinoma have changed over the past 20 years and continue to do so. New entities have been described and molecular analyses have suggested better characterisation and grouping of certain tumours. Because some of the lesions have been named differently by different authors, clinicians and patients may be confused as to what a specific patient's lesion represents. In this review, we discuss the thyroid tumours of follicular origin which are clinically unusual but important to recognise as their behaviour may be aggressive, they may not respond to radioiodine treatment and they may cause significant mortality. This paper describes these important but rare lesions, their pathological features, important clinicopathological correlations, molecular correlates and prognostic implications.

  • Thyroid cancer
  • Surgical pathology
  • Neoplasms

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