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Epidemiological investigation and antimicrobial susceptibility analysis of ureaplasma species and Mycoplasma hominis in outpatients with genital manifestations
  1. Tiejun Song1,
  2. Aiqing Ye1,
  3. Xinyou Xie1,
  4. Jun Huang1,
  5. Zhi Ruan1,
  6. Yingying Kong1,
  7. Jingjuan Song1,
  8. Yue Wang2,
  9. Jianzhong Chen3,
  10. Jun Zhang1
  1. 1Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of medicine, Zhejiang University, Hangzhou, China
  2. 2Department of Gynecology & Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China
  3. 3Zhejiang University, Hangzhou, China
  1. Correspondence to Jun Zhang, Department of Clinical Laboratory, Sir Run Run Shaw hospital, School of medicine, Zhejiang University, Hangzhou 310000, China; jamezhang2000{at}163.com

Abstract

Aims The aim of this study was to assess the prevalence and drug resistance of Ureaplasma species and Mycoplasma hominis in outpatients with genital manifestation from 2005 to 2013 in Hangzhou, China.

Methods A total of 2689 female and 2336 male patients with various genital symptoms were included in this study. Species identification and antimicrobial susceptibility test were performed by using the mycoplasma IST-2 kit.

Results The prevalence rate of Ureaplasma species was 39.9%, M hominis was 1.2% in female patients, and the coinfection rate was 13.4%; while in males, the prevalence rate of Ureaplasma species was 18.8%, M hominis was 0.4%, and the coinfection rate was 2.9%. Moreover, significantly high positive rates for mycoplasmas (Ureaplasma species M hominis) and were found in 16–20-year-old females (65.2%) and males (27.3%). Ureaplasma species and M hominis displayed relatively lower resistance rates (<5.0%) to doxycycline, josamycin, tetracycline and pristinamycin, and the resistance rates did not change during the study period, while the resistance rates of Ureaplasma species to quinolones (ofloxacin and ciprofloxacin) were much higher (>50%) and increased significantly from 2005 to 2013.

Conclusions Our study indicates that high positive rates of Ureaplasma species and M hominis were found in young outpatients with genital symptoms, and monitoring the local drug resistance is critical for prevention of the occurrence of resistant strains.

  • Epidemiology
  • Mycoplasmas
  • Antimicrobial Resistance

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