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Young-age prostate cancer
  1. S Hussein1,
  2. S Satturwar2,
  3. T Van der Kwast2
  1. 1Department of Laboratory Medicine, Kuwait Cancer Control Center, Kuwait, Kuwait
  2. 2Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
  1. Correspondence to Professor Theo H Van der Kwast, Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; theodorus.vanderKwast{at}uhn.ca

Abstract

Although prostate cancer is a disease of the elderly, its diagnosis is not uncommonly made in men younger than 55 years. Both ethnic, familial and genetic factors play a role in the early onset of prostate cancer, but the biology, particularly of low-grade prostate cancers detected at young age is not well understood. Autopsy studies have shown a high prevalence of Gleason score 6 prostate cancers in men under 55 years, but mortality of prostate cancer at this young age is almost negligible. Recently, a number of susceptibility genes such as BRCA2 and HOXB13 were reported, each with their own specific biological and histopathology features. In this review, we provide an update on the most recent findings in young-age prostate cancer.

  • UROGENITAL PATHOLOGY
  • EPIDEMIOLOGY
  • GENETICS

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