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I have read with great interest the paper of Shon et al1 demonstrating ERG expression in chondrogenic bone and soft tissue tumours, using an ERG monoclonal antibody against the N-terminus of this molecule (9FY, 1:50-1:100, BioCare). Based on the recent publication of Stockman et al2 showing that ERG antibodies directed against the C-terminus are less likely to label epithelioid sarcoma compared with those directed against the N-terminus, I prefer the anti-C-terminus ERG monoclonal antibody (EPR3864(2), 1:2000, Epitomics) instead of the anti-N-terminus ERG monoclonal antibody as relatively specific diagnostic marker of endothelial differentiation and as marker for Ewing sarcomas with EWSR1-ERG rearrangement.3 …
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