Footnotes

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• Contributors CLeMdS contributed with the study conception, data acquisition and analysis; she wrote the article and gave final approval of the version to be published, and she is responsible for all aspects of the work. CBB and MAT contributed with data acquisition; they revised the article and gave final approval of the version to be published, and they are responsible for all aspects of the work. EDRPV and PAAS contributed with data acquisition and analysis; they revised the article and gave final approval of the version to be published, and they are responsible for all aspects of the work. VOF contributed with the study design, data analysis and interpretation; he helped in writing the article and gave final approval of the version to be published, and he is responsible for all aspects of the work. NH contributed with the study design, data interpretation and analysis; he revised the article critically and gave final approval of the version to be published, and he is responsible for all aspects of the work. PVC contributed with the study design, data acquisition, interpretation and analysis; he wrote and revised the article critically, and gave final approval of the version to be published, and he is responsible for all aspects of the work. RPC and NSB performed flow cytometry studies and revised the paper. CLPM contributed in the writing and revision of the paper. JFF took care of the patient; contributed in the writing and revision of the paper.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.