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Molecular characteristics and potential therapeutic targets in Merkel cell carcinoma
  1. Shakuntala H Mauzo1,
  2. Renata Ferrarotto2,
  3. Diana Bell3,
  4. Carlos A Torres-Cabala3,
  5. Michael T Tetzlaff3,
  6. Victor G Prieto3,
  7. Phyu P Aung3
  1. 1Department of Pathology, The University of Texas Health Science Center, Houston, Texas, USA
  2. 2Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  3. 3Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  1. Correspondence to Dr Phyu P Aung, Department of Pathology, Unit 0085, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA; aungpatho{at}gmail.com

Abstract

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumour occurring preferentially in elderly and immunosuppressed individuals. Multiple studies have provided insight into the molecular alterations of MCC, leading to the design of several ongoing clinical trials testing chemotherapy, targeted therapy and immunotherapy in patients with recurrent or metastatic disease. The results of some of these studies are available, whereas others are eagerly awaited and will likely shed light on the understanding of MCC biology and potentially improve the clinical outcomes of patients with this rare disease.

  • CARCINOMA
  • DERMATOPATHOLOGY
  • NEUROENDOCRINE TUMOURS
  • SKIN

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