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The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes
  1. Sangeetha N Kalimuthu,
  2. Stefano Serra,
  3. Neesha Dhani,
  4. Runjan Chetty
  1. Departments of Pathology, Laboratory Medicine Program and *Medical Oncology, University Health Network and University of Toronto, Toronto, Canada
  1. Correspondence to Dr Sangeetha Kalimuthu, Department of Pathology, University Health Network, University of Toronto, Toronto General Hospital, 11th floor, Eaton wing, 200 Elizabeth Street, Toronto Ontario, Canada M5G 2C4; kalimuthu.sangeetha{at}


Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.


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