Article Text

PDF
PD-L1
  1. Anthousa Kythreotou1,
  2. Abdul Siddique1,
  3. Francesco A Mauri1,
  4. Mark Bower2,
  5. David J Pinato1
  1. 1Departmentof Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK
  2. 2National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK
  1. Correspondence to Dr David J Pinato, NIHR Academic Clinical Lecturer in Medical Oncology, Imperial College London, Hammersmith Hospital Campus, London W120HS, UK; david.pinato09{at}imperial.ac.uk

Abstract

Programmed death ligand 1 (PD-L1) is the principal ligand of programmed death 1 (PD-1), a coinhibitory receptor that can be constitutively expressed or induced in myeloid, lymphoid, normal epithelial cells and in cancer. Under physiological conditions, the PD-1/PD-L1 interaction is essential in the development of immune tolerance preventing excessive immune cell activity that can lead to tissue destruction and autoimmunity. PD-L1 expression is an immune evasion mechanism exploited by various malignancies and is generally associated with poorer prognosis. PD-L1 expression is also suggested as a predictive biomarker of response to anti-PD-1/PD-L1 therapies; however, contradictory evidence exists as to its role across histotypes. Over the years, anti-PD-1/PD-L1 agents have gained momentum as novel anticancer therapeutics, by inducing durable tumour regression in numerous malignancies including metastatic lung cancer, melanoma and many others. In this review, we discuss the immunobiology of PD-L1, with a particular focus on its clinical significance in malignancy.

  • cancer
  • oncogenes
  • immunology

Statistics from Altmetric.com

Footnotes

  • Handling editor Runjan Chetty

  • Contributors Conception or design: DJP. Acquisition, analysis or interpretation of data: AK, AS, FAM, MB and DJP. Drafting the work or revising it critically for important intellectual content: AK, AS, FAM, MB and DJP. Final approval of the version to be published: AK, AS, FAM, MB and DJP.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.