eLetters

70 e-Letters

published between 2003 and 2006

  • Re: Assessment of the Cardiff nephrectomy cut-up protocol with total blocking of the renal sinus (1)
    Patricia Harnden

    Dear Editor

    This interesting paper raises important points regarding the staging of renal carcinomas using the TNM classification of malignant tumours (2). In particular, one of the take-home messages was the need for further clarification of the type of vessel that must be invaded for tumours to be staged as pT3b. In fact, clarifications regarding the staging system for renal tumours had been sought from the TNM com...

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  • Microbial pathogens and atherosclerosis
    Kenneth A Hoekstra, PhD

    Dear Editor

    In the article by Weiss et al. 'No evidence for a direct role of Helicobacter pylori and Mycoplasma pneumoniae in carotid artery atherosclerosis' the authors conclude that the absence and/or random distribution of select pathogens (i.e. H pylori and M pneumoniae) precludes their direct role in the development of atherosclerosis. Given the rather small sample size of this study (36 patients), and the larg...

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  • HIV enteropathy
    Philip A Batman

    Dear Editor

    Re: My Approach. An approach to duodenal biopsies

    We read with interest the section in this review of duodenal pathology describing AIDS enteropathy. However, the histological description of the lesion by Serra and Jani 1 does not accurately reflect the majority of literature on the subject and the comments regarding pathogenesis are confused.

    The pathogenesis of villous at...

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  • Oncocytic features in rectal adenocarcinoma
    Maria P. Foschini

    Dear Editor

    We read with interest the paper entitled “Rectal adenocarcinoma with oncocytic features: possible relationship with pre-operative chemoradiotherapy” published in the October issue of this journal (1). In this paper 5 cases of rectal carcinomas mainly composed of oncocytic cells are reported. All the five cases underwent radio and chemotherapy before surgery. The Authors suggest t...

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  • Re: Zhang H, Xu L, Xiao D et al. Fascin is a potential biomarker for early-stage
    Olorunda Rotimi

    Dear Editor

    I read with interest the article by Zhang et al published in the September 2006 issue of the Journal of Clinical Pathology (J Clin Pathol 2006;59:958–964.). The authors wrote on fascin, an actin-binding protein, as a potential biomarker for early-stage oesophageal squamous cell carcinoma. There are a number of methodological issues with the research and paper that potentially weakens their findings and int...

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  • Best Practice in Primary Care Pathology
    Philip H Evans

    Dear Editor

    Smellie et al, in their article Best Practice in Primary Care Pathology: Review 3(1) cite our article published in the BMJ in 1994.(2)

    Unfortunately they state that this was a study of “people referred from primary care to a hospital lipid clinic” and it wasn’t. Our study was, on the contrary, a review of computerised medical records of a group of patients with hyperlipidaemia in one general prac...

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  • A quality work?
    Jeevan P Marasinghe

    Dear Editor,

    Nakhleh R E (1) has excelled in giving us a brilliant account on the quality assuarance and improvement plan in surgical pathological reporting in a nutshell. An accurate, comprehensive, brief and timely surgical pathology report would always facilitate the optimum management of the patient and it would also satisfy the needs of the customer, in this case the clinician.Undoubtably all the clinicians...

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  • Re: Basal-like breast carcinomas
    Rosella Silvestrini

    Dear Editor,

    I recently read the article, "Basal-like breast carcinomas; clinical outcome and response to chemotherapy" by Banerjee et al. (corresponding author, Prof. Smith), published online in Journal of Clinical Pathology on 23.03.06. I would like to point out that the authors incorrectly make reference to a paper of mine (reference 3), published in Journal of Clinical Oncology in 1995, in connection with g...

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  • Reimbursement for Assay Tests
    Gregory D. Pawelski

    Dear Editor,

    The traditional criteria ever used to evaluate laboratory tests has been the predictive 'accuracy' of the test.

    None of the available laboratory tests used in the selection of treatments for cancer patients have ever been tested for 'efficacy'. This includes estrogen receptor, progesterone receptor, Her2/neu, immunohistochemical staining for tumor classification, bacterial culture and sensi...

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  • Moving beyond the gross appearance: the value of an accurate histological analysis
    Fabio De Giorgio

    Dear Editor,

    We read with great interest the original article by Bernardi et al. [1] in the December 2005 issue of the Journal. According to literature previously published, the authors believe that necroscopy is the standard method to determine the cause of death when investigating clinicopathological discrepancies and the epidemiology of disease. They reviewed the provisional and final reports of necropsies per...

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