eLetters

48 e-Letters

published between 2006 and 2009

  • Her2 Neu, BRCA1 or Telomere in Breast Cancer?
    Professor Pranab Kumar Bhattacharya

    Dear Editor,

    Elizabeth H Blackburn and Jack Szostak discovered that a unique DNA sequence in the telomeres protects chromosomes from degradation. Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase. If the telomeres are shortened, cells age....

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  • A casual role for Human Papilloma virus-16 for the Head and Neck Cancers word wide-
    Professor Pranab Kumar Bhattacharya

    A casual role for Human Papilloma virus-16 for the Head and Neck Cancers word wide-and role of HPV vaccine altering the carriage rate of oropharyngeal HPV16?

    Dear Editor

    Infection with Human Papilloma Virus (HPV) 16 and 18 mostly is well established for development of cervical cancers in pre and post menopausal women through out the world. Professor H. Zur Housen was awarded the Nobel Prize for medicine an...

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  • Response from Authors
    Norman J Carr

    Dear Editor

    We thank Drs Rotimi and Reall for their comments, but would suggest that their criticisms have been framed by a perspective that is different from our own. Their perspective is the “most striking result” was that sessile serrated adenomas (SSAs) were predominantly right sided. They are welcome to highlight this point, which is readily apparent from the data presented.

    Our perspective is t...

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  • Response from authors
    Emina A Torlakovic

    Dear Editor,

    We fully support the integrated approach to hematopathological diagnostics, which has been advanced by the WHO 2008 classification and we acknowledge the prominent role of immunophenotyping in this classification (1). The integrated approach is still not fully applied even in the most advanced countries. In some other countries, (hemato)pathologists still struggle, having only bone marrow (BM) tissue...

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  • Serrated and non-serrated polyps of the colorectum...
    Olorunda Rotimi

    Dear Editor,

    Re: Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma

    We read with interest the article by Carr NJ et al (J Clin Pathol 2009;62:516-518). The article describes the prevalence of different colorectal polyps in an unselected population with a focus speci...

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  • External QA for bone marrow biopsies. Why is there such a need?
    Attilio Orazi

    Dear Editor

    The authors use sweeping generalizations to make their case. This is just one example: "while the role of external quality assurance programs is well established as a valuable tool for QA/QC in diagnostic immunohistochemistry in surgical pathology, such approaches are notably lacking in bone marrow biopsy pathology". However, in reality, no published data support a need for an external QA/QC program fo...

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  • Peritoneal lymphomatosis with rasised CA125: cytology with flow cytometry helps in the diagnosis
    Hui-Hua Hsiao

    Dear Editor,

    Dr. Aslam presented a rare case with peritoneal lymphomatosis and concluded that a histologic examination is crucial in the diagnosis, while cytology might sometimes mislead the workup.1 However, we present here another such case with raised CA 125 and demonstrate that cytology with a flow cytometry examination can help in the diagnosis.

    This 44-year-old female suffered from autoimmune disord...

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  • Which is the cart and which the horse?
    Richard G Fiddian-Green
    Which is the cart and which the horse?

    Dear Editor,

    In HL-60 cells lovastatin reduces the intracellular pH in dose- dependent manner and the fall in pH correlates with the extent of DNA degradation (1). More importantly alkalinization suppresses lovostatin-induced apoptosis. A fall in pH is an indication of reductive stress, a stimulus for the expression of HIF, VEGF and NOS. A normal or elevated pH may also be nece...

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  • First case of nodal marginal zone B-cell lymphoma arising of intraparotidal Warthin's tumour
    Olivia ZIMMER

    Dear Editor

    Warthin tumor (WT) of the salivary gland (so called papillary cystadenoma lymphomatosum or adenolymphoma) is a benign neoplasm of the salivary gland epithelium with a proliferative epithelial component associated with a variably prominent stroma.[1] As reported by Saxena [1], histogenesis of this entity is very controversial. WT and malignant lymphoma are rarely associated, and most are examples of invo...

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  • Toxin production in fishing vessels
    Stephen J James

    Dear Editor,

    I was very interested to read your article which was based on work we carried out a number of years ago. We feel it is important that the safety aspects of handling fish under the conditions described in the work are widely publicised.

    If readers would like a more detailed account of the work carried out they will find it in: James, S.J., James, C , Jones, S & Swain, M.J. 2000 Toxin productio...

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