eLetters

156 e-Letters

  • " Colonic mucosa control in Cdx2 score based diagnosis of BO related metaplasia, dysplasia, adenocarcinoma"
    Mohammed Naim
    Ref:Immunohistochemical assessment for Cdx2 expression in the Barrett metaplasia-dysplasia-adenocarcinoma sequence; This original study confirms to its cited and previous reports on Cdx2 expression in BO related intestinal metaplasia and its downregulation with the evolution of lesion to dysplasia and adenocarcinoma.[1] A well documented research communication about authors' confirmation and conclusion that the Cdx2 down regulatio...
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  • NF-kB and ER appeared remotely coordinated by EGFR
    Mohammed Naim

    This study from multiple centers of repute from UK and Spain demonstrated cytoplasmic and nuclear expressions of NF-kB/p65, and established that in good number-ratio of 1:4 or 1:3 cytoexpression was followed/accompanied by the nuclear expression, besides there were cases of breast carcinoma negative for nuclear as well as cyto expression of NF- kB; could imply that p65 expression was consequence rather than being an esse...

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  • Serum or Plasma? Pseudohyperkalemia in a chronic lymphocytic leukemia patient
    Kenneth A. Hoekstra

    Dear Editor:

    Kapoor et al. (1) investigated pseudohyperkalemia in outpatients and attributed many of the cases to hematological abnormalities or delay in specimen centrifugation or clotting. Plasma is often recommended as the preferred specimen in patients with leukocytosis, erythrocytosis or thrombosis (2). Potassium released from ruptured cells during the clotting process of serum specimens may result in false...

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  • Intervention to reduce mortality due to the alcohol-related road traffic collision
    Masahito Hitosugi

    Editor - The article "Alcohol and unnatural death in the West of Ireland: a 5-year review" emphasized the need for effective interventions to reduce mortality due to the alcohol-related road traffic collision (RTC)[1]. Recently in Ireland, allowable blood alcohol concentration (BAC) limit of drivers was decreased from 0.8mg/ml to 0.5mg/ml. According to Ingoldsby and Callagy concluded in their manuscript that legislative...

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  • The ubiquitous mitochondrial toxin, valinomycin, and its role in the etiology of the CFS
    Joseph W Arabasz MD

    Dear Drs Kaushik, Fear, Richards, McDermott, Nuwaysir, Kellam, Harrison, Wilkinson, Tyrrell, Holgate, Kerr, and Editors at JCP,

    I hope this note finds you well. Congratulations to the Physicians and Researchers who completed such admirable work regarding the possible etiology of the CFS (Chronic Fatigue Syndrome), as they made the observations that were "consistent with a complex pathogenesis involving T...

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  • arguably no government health warning from TSH 4.8-33 mU/l in the elderly
    oscar,m jolobe

    Dear Editor

    Of all the prospective candidates for thyroid replacement therapy(1), even when due account is taken of the improvent in left ventricular diastolic function attributable to this treatment modality in patients of mean age 39.9 with subclinical hypothyroidism(SCH)(2), the over 65s with SCH are probably the ones least likely to be at cardiovascular disadvantage if they do not receive thyroid replacement t...

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  • Re:Ethnic differences in glycated haemoglobi: a comment
    Taruna Likhari

    Dear Editor

    We are astonished by Wiwanitkit's inaccurate remarks regarding the number of subjects studied and analytical methodology in our study [1]. The data set was of more than sufficient size to be subjected to rigorous statistical analyses. If Wiwanitkit had bothered to even casually read the articles he cites [1,2], he should have immediately realised that firstly the thrust of Lenters-Westra's and Sling...

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  • Ethnic differences in glycated haemoglobi: a comment
    professor viroj wiwanitkit

    Dear Editor,

    I read the recent publication by Likhari et al with a great interest [1]. Likhari et al concluded that "In subjects with similar fasting and postprandial glycaemia on OGTT, those of South Asian origin have higher HbA(1c) levels than white subjects. It is speculated that the higher glycaemia-independent HBA1c levels in people of South Asian origin could possibly contribute to their increase cardiovas...

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  • Her2 Neu, BRCA1 or Telomere in Breast Cancer?
    Professor Pranab Kumar Bhattacharya

    Dear Editor,

    Elizabeth H Blackburn and Jack Szostak discovered that a unique DNA sequence in the telomeres protects chromosomes from degradation. Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase. If the telomeres are shortened, cells age....

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  • A casual role for Human Papilloma virus-16 for the Head and Neck Cancers word wide-
    Professor Pranab Kumar Bhattacharya

    A casual role for Human Papilloma virus-16 for the Head and Neck Cancers word wide-and role of HPV vaccine altering the carriage rate of oropharyngeal HPV16?

    Dear Editor

    Infection with Human Papilloma Virus (HPV) 16 and 18 mostly is well established for development of cervical cancers in pre and post menopausal women through out the world. Professor H. Zur Housen was awarded the Nobel Prize for medicine an...

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