Regular ArticleMolecular Pathogenesis of Pituitary Tumors☆
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Association between intracranial aneurysm and meningiomas: An integrative survival Analysis with identification of prognostic factors
2020, Clinical Neurology and NeurosurgeryCitation Excerpt :This occurrence was an obvious independent predictor for survival. This fact should draw attention to the urgency of the proper management of these patients, who in themselves already have factors that may contribute to increased intracranial pressure due to the presence of the tumor [7,10,19]. Regarding treatment, most patients had tumor-related symptoms and surgical treatment subsequent to diagnosis showed an impact on overall survival, however, one should take into account the patient's previous conditions, surgical indications, and prognostic factors [6,23].
Relationship between expression of vascular endothelial growth factor and the proliferation of prolactinomas
2017, Clinical Neurology and NeurosurgeryCitation Excerpt :Furthermore, prolactinomas have the highest rate of recurrence post-surgery as compared with other pituitary adenomas [23]. Many factors may influence the proliferation of pituitary adenomas, such as angiogenesis, apoptosis, growth factors, oncogenes, tumor suppressor genes, and hormone receptors [25,26]. However, little is known about the role of VEGF expression in the process of the growth of prolactinomas.
CAMP signalling in the normal and tumorigenic pituitary gland
2014, Molecular and Cellular EndocrinologyCitation Excerpt :Gain-of-function mutations in this oncoprotein result in a constitutively active G protein coupled receptor, inhibition of intrinsic α subunit GTPase activity, increased AC activity in response to ligand binding and ultimately higher cAMP levels (Vallar et al., 1987; Landis et al., 1989). Mutations within this gene are mostly found in two hotspots, at residues 201 and 227 on the maternally imprinted allele (Farrell and Clayton, 2000). However, sommatotropinoma patients with GNAS mutations have been reported to have higher (Harris, 1988), lower (Buchfelder et al., 1999; Yang et al., 1996; Adams et al., 1993) or unchanged plasma GH levels (Yasufuku-Takano et al., 2006) compared to patients with no GNAS mutations.
Differential expression of cyclin D1 in human pituitary tumors: Relation to MIB-1 and p27/Kip1 labeling indices
2011, Journal of the Egyptian National Cancer InstituteCitation Excerpt :However in addition to amplification, inappropriate cyclin D1 expression may be due to another principal mechanism which is cytogenic inversion as described in parathyroid tumors [30]. This is further highlighted in the few reports on the cyclin D1 overexpression and its genetic alteration in pituitary adenomas suggesting that the overexpression of cyclin D1 occurs early and late in pituitary tumorigenesis and this is not necessarily associated with cyclin D1 gene allelic imbalance [13,16,31]. In our study, a significant positive correlation was noted between cyclin D1 and tumor recurrence, which was previously described in squamous cell carcinoma of the head and neck [9].
Gene expression changes in the pituitary gland of rats exposed to electromagnetic pulses
2011, Biomedical and Environmental SciencesPathology of the Pituitary and Sellar Region
2010, Practical Surgical Neuropathology: A Diagnostic Approach A Volume in the Pattern Recognition Series, Expert Consult: Online and Print
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