Regular Articlep53 Overexpression and bcl-2 Persistence in Endometrial Carcinoma: Comparison of Papillary Serous and Endometrioid Subtypes
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Proliferative and apoptotic changes in the healthy canine endometrium and in cystic endometrial hyperplasia
2018, TheriogenologyCitation Excerpt :Regeneration of the endometrium and preparation for the next proliferation phase are mainly linked to apoptotic processes, where imbalances in the expression of Bcl-2 and Bax may induce pathological conditions like endometrial hyperplasia [16]. The development of endometrial hyperplasia in women is supposed to be caused by changes in proliferation [16,17,20], and intensified through deregulation of apoptosis, mainly due to an overexpression of Bcl-2 [15,17,21–24]. Therefore human endometrial hyperplasia is considered to be a precancerous lesion with a potential for developing neoplastic processes [17,24,25].
Endometrial Cancer Genomics
2017, Translational Advances in Gynecologic CancersUterine papillary serous cancer: A review of the literature
2012, Gynecologic OncologyCitation Excerpt :EEC is associated with inactivation of the PTEN tumor-suppressor gene, mutations in β-catenin and K-ras (Kirsten rat sarcoma viral oncogene), and defects in DNA mismatch repair resulting in microsatellite instability [41]. In contrast, UPSC displays frequent p53 (tumor protein 53) gene mutations, and human epidermal growth factor receptor 2 or HER-2-neu (human epidermal growth factor receptor 2) gene amplification [42,43]. Several studies have shown HER-2-neu overexpression in 16–62% of UPSC tumors, suggesting that HER-2-neu may be responsible for transformation and tumorigenesis in these cancers [44–46].
Endometrial Cancer
2012, Obstetrics and Gynecology Clinics of North America