Original contributionKeratins 7 and 20 as diagnostic markers of carcinomas metastatic to the ovary
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2020, International Journal of Biochemistry and Cell BiologyCitation Excerpt :While circulating K20 might be an actual prognostic marker for post-surgical tumor burden, cautiousness is still needed when interpreting the results, as studies assessing the presence of K20 in peripheral blood of CRC patients show major variations in their results (Bustin et al., 1999; Schuster et al., 2004; Wang et al., 2006; Shen et al., 2008; Šamija et al., 2013) A majority of K20-positive intestinal carcinomas and metaplasia do not express K7, and K7-negativity can be considered as an additional marker for cancers of intestinal origin (Loy and Calaluce, 1994; Wauters et al., 1995; Wang et al., 1995; Park et al., 2002; Harbaum et al., 2011). This common phenotype has made the combination of K20 and K7 analyses a valid marker of cancers of colonic origin (Table 1), as it is rare to nonexistent in many common adenocarcinomas, such as those of lung, breast, urothelium, liver and ovary (Tot, 2002; Karantza, 2011).
Immunohistochemistry and Molecular Diagnostics in the Differential Diagnosis of Female Genital Tract Pathology
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