Potentiation of antibody responsiveness after the transplantation of a syngeneic pituitary gland☆
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Cited by (53)
System Consolidation During Sleep - A Common Principle Underlying Psychological and Immunological Memory Formation
2015, Trends in NeurosciencesCitation Excerpt :There is likewise evidence that low cortisol concentrations contribute to enhancing T cell homing to lymph nodes, APC–T cell interactions, and the development of persisting T cells during sleep [5,74,78,79,91,92]. Immunological memory consolidation concurrently appears to benefit from growth hormone and prolactin, which are proinflammatory hormones whose release is enhanced by SWS and which are particularly effective within 24 h after inoculation of an antigen [93]. For psychological memory consolidation the role of SWS-associated activation of somatotropic activity and prolactin release is currently less well characterized [94].
Prolactin, neurogenesis, and maternal behaviors
2012, Brain, Behavior, and ImmunityCitation Excerpt :Thus, the increase in prolactin levels during pregnancy may attenuate the potentially harmful effects of the increased glucocorticoid levels on levels of apoptosis of lymphocytes. Prolactin regulates the production of cytokines by T cells (Dimitrov et al., 2004), and also augments the estrogen-derived shift of the balance of the immune response during pregnancy so that humoral immunity (T helper type II lymphocytes) predominates over cell-mediated immunity (T helper type I lymphocytes) (Cross et al., 1989; Gaunt and Ramin, 2001; Ijaz et al., 1990; Szekeres-Bartho, 2002). This shift away from cell-mediated immunity assists in the lack of immune response to the paternally-derived fetal antigens permitting implantation and continuance of the pregnancy.
Prolactin and Autoimmunity
2010, Principles of Gender-Specific MedicineChapter 21 Estrogen and Prolactin: Contributions to Autoimmunity in Murine Models of Systemic Lupus Erythematosus
2008, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :High levels of circulating prolactin stimulate immune responses. In mice, hyperprolactinemia was created by either implanting syngeneic pituitary glands or injecting exogenous prolactin, and primary humoral antibody responses were increased (Cross et al., 1989). Low levels of prolactin in cysteamine-treated mice were associated with thymic atrophy and immune suppression (Bryant et al., 1989).
Prolactin in Autoimmune Disease
2004, Principles of Gender-Specific MedicineUnproven and experimental therapies
2004, Systemic Lupus Erythematosus, Fourth Edition
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Supported by USPHS grants NS17423 and NS22512.