ReviewMast cells as a source of multifunctional cytokines
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2019, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Likewise, vascular instability may be triggered not only by histamine but also by prostaglandins (PGs) and/or leukotrienes (LTs) derived from activated MCs in the same patient, so that the reaction can be managed when administering histamine receptor blockers and PG/LT synthesis inhibitors and/or receptor blockers.32 Other potentially relevant mediators associated with activation of MCs are platelet-activating factor, tryptases, and various cytokines20,31,33-36 (Table IV). MCA may also develop with chronic and/or a less severe symptomatology (Table V).
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2013, Pharmacological ReportsCitation Excerpt :A number of studies reported that mast cells are activated and infiltrated in the skin lesion of the atopic dermatitis animal model, suggesting the contribution of mast cells in atopic dermatitis [4, 9, 25, 30]. The cysteine protease caspase-1 is a member of the caspase family [6]. Quite unlike the role that most caspases have in apoptosis, caspase-1 mainly serves to cleave IL-1β and IL-18 from their inactive precursors to their active forms [2, 16].
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2011, International ImmunopharmacologyCitation Excerpt :A number of studies reported that mast cells are activated and infiltrated in the skin lesion of AD animal model, suggesting the contribution of mast cells in AD [9–14]. Caspase-1 is a member of the caspase family [15]. Quite unlike the role that most caspases have in apoptosis, caspase-1 mainly serves to cleave IL-1β and IL-18 from their inactive precursors to their active forms [16,17].