Original contributionAltered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome
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2019, Behavioural Brain ResearchCitation Excerpt :Another approach in this study is to compare cytokine production of peripheral blood mononuclear cells (PBMCs) after immune stimulation. An early study described increased IL-1β production after LPS challenge to PBMC of CFS patients compared to controls [158]. However, subsequent studies did not confirm this finding, observing lower IL-1β response after an immune challenge in CFS subjects or absence of differences between patients and controls [159,160].
Secreted and intracellular cytokines are complementary measures for human monocytes treated with Toll-like receptor agonists
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2015, Brain, Behavior, and ImmunityCitation Excerpt :One of these studies required patients to fund their own tests (Maes et al., 2012). Seven papers did not state how patients were selected and therefore were unable to score positively for representation (Chao et al., 1991; Kennedy et al., 2004; Neu et al., 2014; Nijs et al., 2009; Patarca et al., 1994; Straus et al., 1989; White et al., 2010, 2004). In terms of control selection, 15 studies recruited from the same community as cases (Table 2).