Tumor angiogenesis as a prognostic factor in oral cavity tumors

doi:10.1016/S0002-9610(05)80079-0

The American Journal of Surgery

Volume 168, Issue 5, November 1994, Pages 373-380

https://doi.org/10.1016/S0002-9610(05)80079-0 Get rights and content

Background:

Lymph-node metastasis is the single greatest predictor of survival in patients with oral cavity cancers. Tumor angiogenesis has been correlated with metastasis in breast cancer and may have prognostic value in other tumors.

Patients and Methods:

Sixty-six patients with clinically node-negative oral cavity squamous cell cancers were reviewed. Samples were cut and stained for factor VIII. The percentage of area of tissue stained for factor VIII was quantitated by a computerized image analyzer. Tumor depth was measured with an ocular micrometer to the nearest 0.1 mm. Variables were statistically examined against regional recurrence.

Results:

The probability of metastasis (%) was 2 for tumor staining of ≤10% and 93 for tumor staining >10% (P <0.0001). The tumor depth was ≤4 mm in 10 and >4 mm in 83 (P <0.0001). Patients with ≤4 mm and ≤10% staining had a 2% rate of recurrence, and patients with >4 mm and >10% staining had a 100% rate of recurrence (P <0.0001).

Conclusion:

Although tumor thickness was suggestive of predictibility, only angiogenesis was a statistically significant predictor of recurrence in a multivariate analysis (P <0.0001). Angiogenesis showed a strong correlation with regional recurrence and may be used as an independent prognostic indicator.

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^*: Presented at the joint meeting of the Society of Head and Neck Surgeons and the European Organization for Research and Treatment of Cancer (EORTC), Paris, France, May 25–28, 1994.

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Resident Clinical AwardTumor angiogenesis as a prognostic factor in oral cavity tumors*

Background:

Patients and Methods:

Results:

Conclusion:

Surg Clin North Am

Hum Pathol

Am J Surg

Am J Surg

J Craniomaxillofac Surg

Lancet

Prognostic factors in oral squamous carcinoma and their relation to clinical staging

Clin Otolaryngol

Nodal metastasis and prognosis in carcinoma of the oral cavity

Otolaryngol Clin North Am

Colorectal cancer