Original contributionIncidence of extramural venous invasion in colorectal carcinoma: Findings with a new technique
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Cited by (33)
Incidence of extramural venous invasion in colorectal carcinoma as determined at the invasive tumor front and its prognostic impact
2019, Human PathologyCitation Excerpt :In the case of macroscopically unambiguous infiltration of the mesocolon/mesorectum, first, 5-mm–thick sections were prepared from the entire tumor. Afterward, the tissue sections were prepared for determination of EMVI by tangential (perpendicular) cutting beginning in the adipose tissue and then including the whole tumor extension; the boundary zone between the tumor and mesocolon and the tumor and periproctal connective tissue, respectively, in Dukes B, C, and D (beyond UICC stage I) tumors of the colon and rectum (Fig. 2); and the boundary between the bowel wall and surrounding fatty tissue at the level of Dukes A (UICC stage I) cancers [10]. In the case of intramural tumors, the border zone between the tunica muscularis propria and the mesocolon/mesorectum was sectioned parallel to the longitudinal axis of the intestine.
Developments in the assessment of venous invasion in colorectal cancer: Implications for future practice and patient outcome
2012, Human PathologyCitation Excerpt :In this way, multiple vessels can be sectioned transversely as opposed to longitudinal sections being obtained of individual vessels (Fig. 1). Among studies that have used tangential sectioning techniques, VI detection rates of 43% to 54% have been reported [21,25,37]. It has also been suggested that blocks taken across the mesentery are an efficacious means of detecting VI [37].
Incidence of synchronous liver metastases in patients with colorectal cancer in relationship to clinico-pathologic characteristics. Results of a German prospective multicentre observational study
2012, European Journal of Surgical OncologyCitation Excerpt :These patients clearly had more synchronous liver metastases than V0 staged cases. The relationship between V category and metastatic colorectal cancer has already been reported in several pathologic studies.19–21 The number of analyzed patients was always small.
TNM staging system of colorectal carcinoma: Surgical pathology of the seventh edition
2011, Diagnostic HistopathologyCitation Excerpt :Several authors have endorsed elastic tissue stains (Figure 10a–b) for the detection of venous invasion.151–156,158 A different approach to increasing the detection of venous invasion is to examine a larger number of veins by increasing the number of tissue blocks submitted and the number of slides examined,152,159–161 or by submitting tangential blocks in addition to perpendicular blocks.152,159,162 Tumour deposits (TDs) are discrete nodules of adenocarcinoma deposited in pericolonic and perirectal fat.
Local recurrence in rectal cancer can be predicted by histopathological factors
2009, European Journal of Surgical OncologyCitation Excerpt :However, there is no agreement, because this is labour intensive, time consuming, relatively expensive and results are contradictory.10,19 Incidence of venous invasion also depends on sampling and assessment of the resection specimen.26,27 In our study, patients with positive lymph nodes had a lower risk to develop LR on multivariate analysis (enter method).