Prognostic significance and effect of chemoradiotherapy on microvessel density (angiogenesis) in esophageal Barrett's esophagus-associated adenocarcinoma and squamous cell carcinoma

doi:10.1016/S0046-8177(99)90135-1

Human Pathology

Volume 30, Issue 7, July 1999, Pages 753-758

https://doi.org/10.1016/S0046-8177(99)90135-1 Get rights and content

Abstract

Previous studies have shown that intratumoral microvessel density (IMD) correlates with clinical outcome in a variety of human neoplasms, such as those that arise in the breast, colon, and stomach, suggesting that angiogenesis is important in cancer progression. The aims of this study were to evaluate the prognostic utility of IMD in esophageal Barrett's-associated adenocarcinoma (AdCa) and squamous cell carcinoma (SCC), and to determine the effect of preoperative chemoradiotherapy (chemrad) on this process. Tissue sections of tumor from 67 patients with esophageal carcinoma (45 with Barrett's-associated AdCa, 22 with SCC) were stained with the vascular marker CD31. The IMD was calculated by evaluating at least 5 different 200 × fields of tumor hot spot areas to obtain the mean microvessel count (MVC). The data then were correlated with the clinical and pathological features, chemrad status, and patient survival. The MVC was significantly higher in AdCa (143 ± 63.2) compared with SCC (77.2 ± 38.6, P = 0.0001). In AdCa, no correlation was noted between the MVC and any of the clinical or pathological features, including chemrad status. In contrast, in SCC, a statistically significant higher MVC was detected in patients who did not receive chemrad (97.2 ± 37.3) compared with those who did (48.3 ± 15.9, P = .002) and in tumors that were larger in size (P = .02). However, the MVC did not correlate with survival in either AdCa or SCC (P > .05). The degree of angiogenesis is not a significant prognostic indicator in either esophageal AdCa or SCC. Preoperative chemrad has a positive effect on reducing the degree of angiogenesis in esophageal carcinoma, particularly SCC.

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^☆: Presented in part at the Annual American Gastrointestinal Association Meeting, New Orleans, LA, May 1998.

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Original contributionPrognostic significance and effect of chemoradiotherapy on microvessel density (angiogenesis) in esophageal Barrett's esophagus-associated adenocarcinoma and squamous cell carcinoma☆

Abstract

Ann Thorac Surg

J Biol Chem

Eur J Can

Eur J Cancer

Lancet

Hum Pathol

Ann Oncol

Pathologic prognostic factors in Barrett's-associated adenocarcinoma: A follow-up study of 96 patients

Cancer

Esophageal squamous cell carcinoma: Pathology and prognosis

World J Surg

National cancer data base report on esophageal carcinoma

Cancer

Prognosis of early esophageal cancer: Comparison between adeno- and squamous cell carcinoma

Cancer

Evaluation of the new (1987) TNM classification for thoracic esophageal tumors

Int J Cancer

Growth and metastasis of tumour in organ culture

Cancer

Angiogenesis and breast cancer

J Clin Oncol

Angiogenesis as a prognostic marker in breast carcinoma with conventional adjuvant chemotherapy: A multiparametric and immunohistochemical analysis

J Pathol

Intratumor microvessel density as a prognostic factor in cancer

Am J Pathol

Tumour angiogenesis and metastasis: Correlation in invasive breast carcinoma

N Engl J Med

Tumour angiogenesis correlates with metastasis in invasive prostate carcinoma

Am J Pathol

Intratumoral microvessel density and p53 protein: Correlation with metastasis in head-and-neck squamous-cell carcinoma

Int J Cancer

Tumor invasion and angiogenesis in early esophageal squamous cell carcinoma

J Surg Oncol

Tumor vascularization and prognosis in squamous cell carcinomas of the esophagus

Anticancer Res

Tumor vascularity correlates with the prognosis of patients with esophageal squamous cell carcinoma

Cancer

Original contribution
Prognostic significance and effect of chemoradiotherapy on microvessel density (angiogenesis) in esophageal Barrett's esophagus-associated adenocarcinoma and squamous cell carcinoma☆