Cell Biology of the Basophil
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Cited by (34)
Functional blood cell analysis by label-free biosensors and single-cell technologies
2022, Advances in Colloid and Interface ScienceCitation Excerpt :Such approaches based on cell surface marker expression were successfully implemented to monitor oral immunotherapy efficacy in food allergy [188]. Importantly from the point of the view of the development of label-free approaches, degranulation of Basophils also triggers morphological changes [189]. These cells highly express FcεRI, and when cross-linked through IgE and allergens, their activation results in the release and de novo synthesis of inflammatory mediators, such as histamine, lipid mediators, cytokines and other inflammatory mediators.
Integrated microRNA and mRNA expression profile analysis of tumor-associated macrophages after exposure to single-dose irradiation
2018, Computational Biology and ChemistryCitation Excerpt :It is quite conceivable that an intracellular pool of CD300a also exists in basophils, which translocates to the cell surface within 20 min of cell stimulation through FceRI (Roederer, 2001). In eosinophils, CD300a expression is also upregulated by hypoxia and GM-CSF, and the inhibition of hypoxia-inducible factor 1 abolished this upregulation (Dvorak, 1998). In summary, in a mouse model receiving single-dose irradiation of 25 Gy, we show differential expression of miRNAs related to cell proliferation and immune responses, in macrophages extracted from irradiated WK2 tumors compared to non-irradiated tumors.
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