Elsevier

The Lancet

Volume 356, Issue 9246, 9 December 2000, Pages 1981-1982
The Lancet

Research Letters
Ep-CAM overexpression in breast cancer as a predictor of survival

https://doi.org/10.1016/S0140-6736(00)03312-2Get rights and content

Summary

The epithelial glycoprotein Ep-CAM is overexpressed in colon cancer and breast cancer. We assessed the frequency and prognostic significance of Ep-CAM in tissue specimens from 205 patients with invasive breast cancer, by immuno-histochemical staining with a monoclonal antibody specific for the Ep-CAM antigen. Ep-CAM overexpression was found in 35·6% of samples and was associated with poor disease-free and overall survival.

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