Case reportCerebellar granulocytic sarcoma in an infant with CD56+ acute monoblastic leukemia
Section snippets
Case report
An 11 month boy was diagnosed with AML M5 without CNS disease, leucocytosis or organomegaly. A difficult BM aspiration yielded a poor sample, infiltrated by monoblasts, inadequate for cytogenetic analysis or immunophenotyping. A BM trephine biopsy showed 90% infiltration by monoblasts, grade 2–3 fibrosis and focal haemophagocytosis. Immunohistochemistry of the BM trephine biopsy sections showed CD15+, CD45R/LCA+, CD68 / PGM1+, CD68/KP-1+, lysozyme+, CD34−, CD61−, CD56−, glycophorin c- and focal
Discussion
Extramedullary leukaemia (EML) represents leukemia cells outside the bone marrow and includes granulocytic sarcomas (GS) at any anatomical site, leukaemia cutis (LC) and meningeal leukaemia (ML) [1]. It can be a presenting feature of evolving AML or an antedating/concomitant feature of medullary relapse [1]. The incidence in adult AML was reported to be between 2.9 and 8% during the non-intensive chemotherapy era [1]. Pui et al. found a 4.7% incidence in children with AML. [3]. Suggested
Acknowledgements
The authors would like to thank Dr. I.M. Hann, Consultant Haematologist, Great Ormond Street Hospital London, and Dr. B.J. Bain for their invaluable comments during the preparation of the manuscripts.
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