ADAMs: focus on the protease domain
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ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer
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2021, General and Comparative EndocrinologyTherapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders
2021, Neurochemistry InternationalCitation Excerpt :Also, the administration of glucocorticoid induces a state analogous to anxiety and depression in terms of structural, functional, behavioral and neurochemical alterations (Murray et al., 2008; Zhao et al., 2008; Gourley et al., 2008). Stress is also characterized by the increased release of inflammatory cytokines (such as TNF-α and IL-1) (Dunn et al., 1999) and exposures to only 30 min of restraint stress increase the expression of TNF-α convertase enzyme (TACE) in the brain cortex (Madrigal et al., 2002) responsible for the cleavage of pro-TNF-α into TNF-α (Black and White, 1998). TNF-α so released is responsible for the activation of NF-kb pathway resulting in the inducible degradation of Iκbα and the release of free nuclear factor of kappa beta (NF-kb) followed by its translocation inside the nucleus (Hayden and Ghosh, 2014).
ADAM proteases: Emerging role and targeting of the non-catalytic domains
2019, Cancer LettersCitation Excerpt :Proteolytic processing and subsequent release of membrane-bound proteins is a post-translational mechanism that governs the biological activity of the cleaved molecules [1–3]. This process, referred to as ‘protein ectodomain shedding’, is mediated by membrane-anchored ADAM metalloproteases [4–9], which shed a wide range of membrane-attached proteins implicated in growth factor signaling, cell migration and cell-adhesion [10]. In this mini-review, we will discuss the salient features of this unique class of proteases, the regulation of their activity via conformational rearrangements in their ectodomains and their potential as therapeutic targets during cancer progression.