ADAMs: focus on the protease domain

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Abstract

ADAMs are proteins containing a disintegrin and metalloproteinase domain. Several important insights were provided in the past year regarding ADAM metalloproteinases: ADAM 10 was implicated in the Notch signaling pathway. ADAM 17 was shown to be the long sought after tumor necrosis factor-α convertase and the crystal structure of its metalloproteinase domain was determined.

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