Evaluating tumor biology and oncological disease with positron-emission tomography

doi:10.1016/S1053-4296(98)80044-1

Seminars in Radiation Oncology

Volume 8, Issue 3, July 1998, Pages 183-196

https://doi.org/10.1016/S1053-4296(98)80044-1 Get rights and content

The usefulness of positron-emission tomography (PET) for noninvasive assessment of several biological parameters of neoplastic tissue has been reviewed. Numerous radiotracers have been developed, whose particular distribution in the presence of cancer in vivo serves to distinguish medically relevant properties of the tumor cells with which they associate. That distribution is most accurately determined through use of a PET scanner, to localize and quantify the tracer molecules, in which have been incorporated positron-emitting isotopes. These tracers include hypoxia markers, receptor ligands, substrates for enzymatic modification by the products of expression of specific genes, and precursors of protein anabolism and carbohydrate catabolism. In addition, application of PET to evaluation of patients with some particular cancers has been examined, while placing special emphasis on the level of scientific rigor of the evidence underlying conclusions about appropriate use of PET in oncology.

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^*: Partially supported by funds from the US Department of Energy, Contract No. DE-FCO3-87ER60615, and by an NIH Career Award, No. CA 01669-05.

View full text

Evaluating tumor biology and oncological disease with positron-emission tomography*

Int J Radiat Oncol Biol Phys

Int J Radiat Oncol Biol Phys

Int J Radiat Oncol Biol Phys

Int J Radiat Oncol Biol Phys

Life Sci

Bioorg Med Chem

Nucl Med Biol

J Biol Chem

Semin Nucl Med

Lung Cancer

Nucl Med Biol

Eur J Surg Oncol

Nucl Med Biol

J Urol

Int J Oral maxillofac Surg

Application of annihilation coincidence detection to transaxial reconstruction tomography

J Nucl Med

Design considerations for a positron emission transaxial tomograph (PET III)

IEEE Trans Biomed Eng NS

Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart

The oxygen effect and reoxygenation

Intercapillary distance, oxygen tension and local recurrence in cervix cancer

Scand J Clin Lab Invest

A radiosynthesis of fluorine-18 fluoromisonidazole

J Nucl Med

Effects of hypoxia of the uptake of tritiated thymidine, L-leucine, L-methionine and FDG in cultured cancer cells

J Nucl Med

Re-evaluation of amino acid PET studies: Can the protein synthesis rates in brain and tumor tissues be measured in vivo

J Nucl Med

Uptake of radiolabelled tyrosine and iodomethyl tyrosine in experimental rat tumours: Influence of blood flow and tumour growth rate

J Nucl Biol Med

Standardized uptake value and quantification of metabolism for breast cancer imaging with FDG and L-[1-11C]tyrosine PET

J Nucl Med

Positron tomographic assessment of estrogen receptors in breast cancer: Comparison with FDG-PET and in vitro receptor assays

J Nucl Med

Suicide genes for cancer therapy

Sci Med

Carbon-8 radiofluorniation of purines: A general approach to probe design for gene therapy in humans

A PET reporter gene (PRG)/PET reporter probe (PRP) technology for repeatedly imaging gene expression in living animals

J Nucl Med

Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy

Cancer Res