Original article: general thoracicPrognosis of thymic epithelial tumors according to the new World Health Organization histologic classification
Section snippets
Patients
One hundred and fifty-one consecutive cases of TETs were pathologically confirmed at the Severance Hospital, Seoul, Korea, during the period from 1992 to 2002. This study protocol was approved by the Institutional Review Board of Ethics Committee, and informed written consent was obtained from each study patient. One case was of thymoma with pseudosarcomatous stroma [13], which is not included in the WHO criteria, and therefore excluded.
Diagnosis was by surgical resection in 125 patients,
Comparison of clinical data and Masaoka stage according to WHO subtypes
There were 88 male and 62 female patients. Patient age at the time of surgery and at initial diagnosis ranged from 4 years to 83 years, and averaged 48 ± 14 years. The concordance rate was 95% (14 of 150). Discrepancy was developed in the B2 and B3 combined type and in the differentiation between types AB and B2.
Paralysis from MG, found in 45 cases (30%), was the most frequent presenting symptom. It was related to disease in 48 patients (32.0%) and was most common in types B2 and B3, but was
Comment
Whenthe WHO histologic classification system for TETs was established, elements of all the major existing classification schemes were taken into account. The clinical significance of the Müller-Hermelink classification system as a prognostic factor has been reported on several occasions previously 15, 16. Our results showed that the WHO classification was reliable and reproducible when it was evaluated by experienced pathologists.
We undertook a retrospective study of 150 TET cases that were
Acknowledgements
We thank Dr Woo Ick Yang for the pathologic review and for reclassifying the TET cases. This work was supported by the Korea Science and Engineering Fund through the Cancer Metastasis Research Center at Yonsei University.
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