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Plasminogen Activators in Vascular Remodeling and Angiogenesis

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Abstract

This review considers cellular and molecular mechanisms of the involvement of plasminogen activators in extracellular proteolysis and cell migration and proliferation. The role of plasminogen activators in vascular remodeling in atherosclerosis, restenosis, and angiogenesis is discussed.

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REFERENCES

  1. Vassalli, J.-D., Sappino, A.-P., and Belin, D.-J. (1991) Clin. Invest., 88, 1067-1072.

    Google Scholar 

  2. Saksela, O. (1985) Biochim. Biophys. Acta, 823, 35-65.

    Google Scholar 

  3. Panchenko, E. P., and Dobrovolsky, A. B. (1999) Sport and Culture [in Russian], Moscow.

  4. Vassalli, J.-D. (1994) Fibrinolysis, 8, 172-181.

    Google Scholar 

  5. Saksela, O., and Vihko, K. K. (1986) FEBS Lett., 204, 193-197.

    Google Scholar 

  6. Nakajima, K., Tsuzaki, N., Nagata, K., Takemoto, N., and Kohsaka, S. (1992) FEBS Lett., 308, 179-182.

    Google Scholar 

  7. Sappino, A.-P., Madani, R., Huarte, J., Belin, D., Kiss, J. Z., Wohlwend, A., and Vassalli, J.-D. (1993) J. Clin. Invest., 92, 679-685.

    Google Scholar 

  8. Manchanda, N., and Schwartz, B. S. (1995) J. Biol. Chem., 270, 20032-20035.

    Google Scholar 

  9. Reinartz, J., Schaefer, B., Bechtel, M. J., and Kramer, M. D. (1996) Exp. Cell. Res., 223, 91-101.

    Google Scholar 

  10. Clowes, A. W., Clowes, M. M., Au, Y. P., Reidy, M. A., and Belin, D. (1990) Circ. Res., 67, 61-67.

    Google Scholar 

  11. Pepper, M. S., Sappino, A.-P., Stöcklin, R., Montesano, R., Orci, L., and Vassalli, J.-D. (1993) J. Cell. Biol., 122, 673-684.

    Google Scholar 

  12. Vassalli, J.-D., Dayer, J.-M., Wohlwend, A., and Belin, D. (1984) J. Exp. Med., 159, 1653-1668.

    Google Scholar 

  13. Canipari, R., O'Connell, M. L., Meyer, G., and Strickland, S. (1987) J. Cell. Biol., 105, 977-981.

    Google Scholar 

  14. Leslie, N. D., Kessler, C. A., Bell, S. M., and Degen, J. L. (1990) J. Biol. Chem., 265, 1339-1344.

    Google Scholar 

  15. Sappino, A.-P., Huarte, J., Vassalli, J.-D., and Belin, D. (1991) J. Clin. Invest., 87, 962-970.

    Google Scholar 

  16. Ossowski, L., Clunie, G., Masucci, M.-T., and Blasi, F. (1991) J. Cell. Biol., 115, 1107-1112.

    Google Scholar 

  17. Huarte, J., Belin, D., Bosco, D., Sappino, A., and Vassalli, J. D. (1987) J. Cell. Biol., 104, 1281-1289.

    Google Scholar 

  18. Mazar, A. P., Henkin, Y., and Goldfarb, R. H. (1999) Angiogenesis, 153, 15-32.

    Google Scholar 

  19. Andreasen, P. A., Kjoller, L., Christensen, L., and Duffy, M. (1997) Int. J. Cancer, 72, 1-22.

    Google Scholar 

  20. Holmes, W. E., Pennica, D., Blaber, M., Rey, M. W., Guenzler, W. A., Steffens, G. L., and Heyneker, H. L. (1985) Biotechnology, 3, 923-929.

    Google Scholar 

  21. Appella, E., Robinson, E. A., and Ullrich, S. J. (1987) J. Biol. Chem., 262, 4437-4440.

    Google Scholar 

  22. Stephens, R. W., Bokman, A. M., Myohanen, H. T., Reisberg, T., Tapiovaara, H., Pedersen, N., Gröndahl-Hansen, J., Llinás, M., and Vaheri, A. (1992) Biochemistry, 31, 7572-7579.

    Google Scholar 

  23. Mukhina, S., Stepanova, V., Traktouev, D., Poliakov, A., Beabealashvilly, R., Gursky, Ya., Minashkin, M., Shevelev, A., and Tkachuk, V. (2000) J. Biol. Chem., 275, 16450-16458.

    Google Scholar 

  24. Madison, E. L. (1994) Fibrinolysis, 8, 221-236.

    Google Scholar 

  25. Besser, D., Verde, P., Nagamine, Y., and Blasi, F. (1996) Fibrinolysis, 10, 215-237.

    Google Scholar 

  26. Ried, S., Jager, C., Jeffers, M., van de Woude, G. F., Graeff, H., Schmitt, M., and Lengyel, E. (1999) J. Biol. Chem., 274, 16377-16386.

    Google Scholar 

  27. Stoppelli, M. P., Verde, P., Grimaldi, G., Locatelli, E. K., and Blasi, F. (1986) J. Cell. Biol., 102, 1235-1241.

    Google Scholar 

  28. Pearson, D., Altus, M. S., Horiuchi, A., and Nagamine, Y. (1987) Biochem. Biophys. Res. Commun., 143, 329-336.

    Google Scholar 

  29. Kenagy, R. D., and Clowes, A. W. (1995) Thromb. Res., 77, 55-61.

    Google Scholar 

  30. Van Leeuwen, R. T., Kol, A., Andreotti, F., Kluft, C., Maseri, A., and Sperti, G. (1994) Circulation, 90, 362-368.

    Google Scholar 

  31. Irigoyen, J., Munoz-Canoves, P., and Montero, L. (1999) Cell. Mol. Life Sci., 56, 104-132.

    Google Scholar 

  32. Lijnen, H. R., Zamarron, C., Blaber, M., Winkler, M. E., and Collen, D. (1990) J. Biol. Chem., 265, 5232-5236.

    Google Scholar 

  33. Moller, L. B., Pollanen, J., Ronne, E., Pedersen, N., and Blasi, F. (1993) J. Biol. Chem., 268, 11152-11159.

    Google Scholar 

  34. Andreasen, P. A., Kjoller, L., Christensen, L., and Duffy, M. J. (1997) Int. J. Cancer, 72, 1-22.

    Google Scholar 

  35. Ellis, V., Scully, M. F., and Kakkar, V. V. (1989) J. Biol. Chem., 264, 2185-2188.

    Google Scholar 

  36. Gliemann, J. (1998) J. Biol. Chem., 379, 951-964.

    Google Scholar 

  37. Stefansson, S., Kounnas, M. Z., Henkin, J., Mallampalli, R. K., Chappell, D. A., Strickland, D. K., and Argraves, W. S. (1995) J. Cell. Sci., 108, 2361-2368.

    Google Scholar 

  38. Argraves, K. M., Battey, F. D., MacCalman, C. D., McCrae, K. R., Gafvels, M., Kozarsky, K. F., Chappell, D. A., Strauss, J. F., III, and Strickland, D. K. (1995) J. Biol. Chem., 270, 26550-26557.

    Google Scholar 

  39. Pepper, M. S., Ferrora, N., Orci, I., and Montesano, R. (1991) Biochem. Biophys. Res. Commun., 181, 902-906.

    Google Scholar 

  40. Ellis, V., and Whawell, S. A. (1997) Blood, 90, 2312-2322.

    Google Scholar 

  41. Fears, R. (1989) Biochem. J., 261, 313-324.

    Google Scholar 

  42. Saksela, O., and Rifkin, D. B. (1990) J. Cell. Biol., 110, 767-775.

    Google Scholar 

  43. Naldini, L., Tamagnone, L., and Vigna, E. (1992) EMBO J., 11, 4825-4833.

    Google Scholar 

  44. Plouet, J., Moro, F., and Bertagnolli, S. (1997) J. Biol. Chem., 272, 13390-13396.

    Google Scholar 

  45. Godar, S., Horejsi, V., and Weidle, U. H. (1999) Eur. J. Immunol., 29, 1004-1013.

    Google Scholar 

  46. Lijnen, H. R., van Hoef, B., Lupu, F., Moons, L., Carmeliet, P., and Collen, D. (1998) Arterioscler. Thromb. Vasc. Biol., 18, 1035-1045.

    Google Scholar 

  47. Dumler, I., Weis, A., Mayboroda, O. A., Maasch, C., Jerke, U., Haller, H., and Gulba, D. C. (1998) J. Biol. Chem., 273, 315-321.

    Google Scholar 

  48. Dumler, I., Kopmann, A., Weis, A., Mayboroda, O. A., Wagner, K., Gulba, D. C., and Haller, H. (1999) Arterioscler. Thromb. Vasc. Biol., 19, 290-297.

    Google Scholar 

  49. Resnati, M., Guttinger, M., Valcamonica, S., Sidenius, N., Blasi, F., and Fazioli, F. (1996) EMBO J., 15, 1572-1582.

    Google Scholar 

  50. Konakova, M., Hucho, F., and Schleuning, W. D. (1998) Eur. J. Biochem., 253, 421-429.

    Google Scholar 

  51. Nguyen, D. H., Hussaini, I. M., and Gonias, S. L. (1998) J. Biol. Chem., 273, 8502-8507.

    Google Scholar 

  52. Tang, H., Kerins, D. M., Hao, Q., Inagami, T., and Vaughan, D. E. (1998) J. Biol. Chem., 273, 18268-18272.

    Google Scholar 

  53. Dumler, I., Petri, T., and Schleuning, W.-D. (1993) FEBS Lett., 322, 37-40.

    Google Scholar 

  54. Dear, A. E., Costa, M., and Medcalf, R. L. (1997) FEBS Lett., 402, 265-272.

    Google Scholar 

  55. Rabbani, S. A., Gladu, J., Mazar, A. P., Henkin, J., and Goltzman, D. (1997) J. Cell. Physiol., 172, 137-145.

    Google Scholar 

  56. Goretzki, L., and Mueller, B. M. (1998) Biochem. J., 336, 381-386.

    Google Scholar 

  57. Simon, D. I., Wei, Y., Zhang, L., Rao, N. K., Xu, H., Chen, Z., Liu, Q., Rosenberg, S., and Chapman, H. A. (2000) J. Biol. Chem., 275, 10228-10234.

    Google Scholar 

  58. Kanse, S. M., Kos, C., Wilhelm, O. G., Andreasen, P. A., and Preissner, K. T. (1996) Exp. Cell. Res., 224, 344-353.

    Google Scholar 

  59. Deng, G., Curriden, S. A., Wang, S., Rosenberg, S., and Loskutoff, D. J. (1996) J. Cell. Biol., 134, 1563-1571.

    Google Scholar 

  60. Hoyer-Hansen, G., Behrendt, N., Ploug, M., Dano, K., and Preissner, K. T. (1997) FEBS Lett., 420, 79-85.

    Google Scholar 

  61. Sitrin, R. G., Pan, P. M., Harper, H. A., Todd, R. F., III, Harsh, D. M., and Blackwood, R. A. (2000) J. Immunol., 165, 3341-3349.

    Google Scholar 

  62. May, A. E., Kanse, S. M., Lund, L. R., Gisler, R. H., Imhof, B. A., and Preissner, K. T. (1998) J. Exp. Med., 188, 1029-1037.

    Google Scholar 

  63. Ghosh, S., Brown, R., Jones, J. C., Ellerbroek, S. M., and Stack, M. S. (2000) J. Biol. Chem., 275, 23869-23876.

    Google Scholar 

  64. Carmeliet, P., and Collen, D. (1994) Fibrinolysis, 8, 269-276.

    Google Scholar 

  65. Estreicher, A., Muhlhauser, J., Carpentier, J.-L., Orci, L., and Vassalli, J.-D. (1990) J. Cell. Biol., 111, 783-792.

    Google Scholar 

  66. Mawatari, O., Okamura, K., Matsuda, T., Hamanaka, R., Mizoguchi, H., Higashio, K., Kohno, K., and Kuwano, M. (1991) Exp. Cell. Res., 192, 574-580.

    Google Scholar 

  67. Odekon, L. E., Sato, Y., and Rifkin, D. B. (1992) J. Cell. Physiol., 150, 258-263.

    Google Scholar 

  68. Morimoto, K., Mishima, H., Nishida, T., and Otori, T. (1993) Thromb. Haemost., 69, 387-391.

    Google Scholar 

  69. Okada, S. S., Tomaszewski, J. A., and Barnathan, E. S. (1995) Exp. Cell. Res., 217, 180-187.

    Google Scholar 

  70. Quax, P. H. A., Boxman, I. L. A., van Kestereen, C. A. M., Verheuen, J. H., and Ponec, M. (1994) Fibrinolysis, 8, 221-228.

    Google Scholar 

  71. Pepper, M. S., Sappino, A.-P., Stocklin, R., Montesano, R., Orci, L., and Vassalli, J.-D. (1993) J. Cell. Biol., 122, 673-684.

    Google Scholar 

  72. Reidy, M. A., Colleen, I., and Lindner, V. (1996) Circ. Res., 78, 405-414.

    Google Scholar 

  73. Carmeliet, P., and Callen, D. (1996) Haemostasis, 26, 132-153.

    Google Scholar 

  74. Ossowski, L. (1992) Cancer Res., 52, 6754-6760.

    Google Scholar 

  75. Okada, S. S., Grobmeyer, S. R., and Barmathan, E. S. (1996) Arterioscler. Thromb. Vasc. Biol., 16, 1269-1276.

    Google Scholar 

  76. Wang, N., Planus, E., Pouchelet, M., Fredberg, J. J., and Barlovatz-Meimon, G. (1995) Am. J. Physiol., 268, C1062-C1066.

    Google Scholar 

  77. Jackson, C. L., and Reidy, M. A. (1992) Ann. N. Y. Acad. Sci., 667, 141-150.

    Google Scholar 

  78. Clowes, A. W., Clowes, M. M., Kirkman, T. R., Jackson, C. L., Au, Y. P. T., and Kenagy, R. (1992) Circ. Res., 70, 1128-1136.

    Google Scholar 

  79. Lu, H., Mabilat, C., Yeh, P., Guitton, J.-D., Li, H., Pouchelet, M., Shoevaert, D., Legrand, Y., Soria, J., and Soria, C. (1996) FEBS Lett., 380, 21-24.

    Google Scholar 

  80. Stepanova, V., Bobik, A., Bibilashvily, R., Belogurov, A., Rybalkin, I., Domogatsky, S., Little, P. J., Goncharova, E., and Tkachuk, V. (1997) FEBS Lett., 414, 417-474.

    Google Scholar 

  81. Gyetko, M. P., Todd, R. R., Wilkinson, C. C., and Sitrin, R. G. (1994) J. Clin. Invest., 93, 1380-1387.

    Google Scholar 

  82. He, C. J., Rebibou, J. M., Peraldy, M. N., Meulders, Q., and Rondeau, E. (1991) Biochem. Biophys. Res. Commun., 176, 1408-1416.

    Google Scholar 

  83. Rabbani, S. A., Desjardin, J., Bell, A. W., Banville, D., Mazar, A., Henkin, J., and Goltzman, D. (1990) Biochem. Biophys. Res. Commun., 173, 1058-1064.

    Google Scholar 

  84. Anichini, E., Fibbi, G., Pucci, M., Chevanne, M., and del Rosso, M. (1994) Exp. Cell. Res., 213, 438-448.

    Google Scholar 

  85. De Petro, G., Copeta, A., and Barlati, S. (1994) Exp. Cell. Res., 213, 286-294.

    Google Scholar 

  86. Shetty, S., Kumar, A., Johnson, A., Pueblitz, S., and Idell, S. (1995) Am. J. Physiol., 268, L972-L982.

    Google Scholar 

  87. Stepanova, V., Mukhina, S., and Kohler, E. (1999) Mol. Cell. Biochem., 195, 199-206.

    Google Scholar 

  88. Rabbani, S. A., Mazar, A., Bernier, S. M., Haq, M., Bolivar, I., Henkin, J., and Goltzman, D. (1992) J. Biol. Chem., 267, 14151-14156.

    Google Scholar 

  89. Ossowski, L., Aguirre Ghiso, J., Liu, D., Yu, W., and Kovalski, K. (1999) Medicina, 59, 547-552.

    Google Scholar 

  90. Dumler, I., Stepanova, V., Jerke, U., Mayboroda, O. A., Vogel, F., Bouvet, P., Tkachuk, V., Haller, H., and Gulba, D. C. (1999) Curr. Biol., 9, 1468-1476.

    Google Scholar 

  91. Langille, B. L. (1993) J. Cardiovasc. Pharmacol., 21, S11-S17.

    Google Scholar 

  92. Cowan, D. B., and Langille, B. L. (1996) Curr. Opin. Lipidol., 7, 94-100.

    Google Scholar 

  93. Schwartz, R. S. (1998) Am. J. Cardiol., 81, 14E-17E.

    Google Scholar 

  94. Lupu, F., Bergonzelli, G. E., Heim, D. A., Cousin, E., Genton, C. Y., Bachmann, F., and Kruithof, E. K. (1993) Arterioscler. Thromb., 13, 1090-1100.

    Google Scholar 

  95. Lupu, F., Heim, D. A., Bachmann, F., Hurni, M., Kakkar, V. V., and Kruithof, E. K. (1995) Arterioscler. Thromb. Vasc. Biol., 15, 1444-1455.

    Google Scholar 

  96. Raghunath, P. N., Tomaszewski, J. E., Brady, S. T., Caron, R. J., Okada, S. S., and Barnathan, E. S. (1995) Arterioscler. Thromb. Vasc. Biol., 15, 1432-1443.

    Google Scholar 

  97. Agrotis, A., and Bobik, A. (1996) Clin. Exp. Pharmacol. Physiol., 23, 363-380.

    Google Scholar 

  98. Galis, Z. S., Sukhova, G. K., Lark, M. W., and Libby, P. (1994) Clin. Invest., 94, 2493-2503.

    Google Scholar 

  99. Van der Bom, J. G., de Knijff, P., Haverkate, F., Bots, M. L., Meijer, P., de Jong, P. T., Hofman, A., Kluft, C., and Grobbee, D. E. (1997) Circulation, 95, 2623-2627.

    Google Scholar 

  100. Hamsten, A., Eriksson, P., Karpe, F., and Silveira, A. (1994) Curr. Opin. Lipidol., 5, 382-389.

    Google Scholar 

  101. Zateishchikov, D. A., Averkov, O. V., Gratsiansky, N. A., Dobrovolsky, A. B., and Storozhilova, A. N. (1992) Kardiologiya, 32, 9-12.

    Google Scholar 

  102. Juhan-Vague, I., and Alessi, M. C. (1997) Thromb. Haemost., 78, 656-660.

    Google Scholar 

  103. Krasnikova, T. L., Parfyonova, Ye. V., Alekseeva, I. A., Arefieva, T. I., Mukhina, S. A., Dobrovolsky, A. B., Titaeva, Y., Lyakishev, A. A., Resink, T. J., Erne, P., and Tkachuk, V. A. (1999) Clin. Exp. Pharmacol. Physiol., 26, 354-357.

    Google Scholar 

  104. Schneiderman, J., Sawdey, M. S., Keeton, M. R., Bordin, G. M., Bernstein, E. F., Dilley, R. B., and Loskutoff, D. J. (1992) Proc. Natl. Acad. Sci. USA, 89, 6998-7002.

    Google Scholar 

  105. Chomiki, N., Henry, M., Alessi, M. C., Anfosso, F., and Juhan-Vague, I. (1994) Thromb. Haemost., 72, 44-53.

    Google Scholar 

  106. Plekhanova, O. S. (2000) Author's abstract of Candidate's dissertation [in Russian], Russian Cardiology Research Center, Moscow.

    Google Scholar 

  107. Kugivama, K., Sakamoto, T., Misumi, I., Sugiyama, S., Ohgushi, M., Ogawa, H., Horiguchi, M., and Yasue, H. (1993) Circ. Res., 73, 335-343.

    Google Scholar 

  108. Tremoli, E., Camera, M., Maderna, P., Sironi, L., Prati, L., Colli, S., Piovella, F., Bernini, F., Corsini, A., and Mussoni, L. (1993) Atheroscler. Thromb., 13, 338-346.

    Google Scholar 

  109. Loskutoff, D. J., Curriden, S. A., Hu, G., and Deng, G. (1999) APMIS, 107, 54-61.

    Google Scholar 

  110. Stary, H. C. (1989) Arteriosclerosis, 9, 119-132.

    Google Scholar 

  111. Blasi, F. (1999) Thromb. Haemost., 82, 298-304.

    Google Scholar 

  112. Falcone, D. J., and Ferenc, M. J. (1988) J. Cell. Physiol., 135, 387-396.

    Google Scholar 

  113. Falkenberg, M., Giglio, D., Bjornheden, T., Nygren, H., and Risberg, B. (1998) J. Vasc. Res., 35, 318-324.

    Google Scholar 

  114. Steins, M. B., Padro, T., Li, C. X., Mesters, R. M., Ostermann, H., Hammel, D., Scheld, H. H., Berdel, W. E., and Kienast, J. (1999) Atherosclerosis, 145, 173-180.

    Google Scholar 

  115. Copeta, A., Tavian, D., Marchina, E., de Petro, G., and Barlati, S. (2000) Growth Factors, 17, 249-268.

    Google Scholar 

  116. Davies, M. J., and Thomas, A. C. (1985) Br. Heart J., 53, 363-373.

    Google Scholar 

  117. Haley, K. J., Lilly, C. M., Yang, J. H., Feng, Y., Kennedy, S. P., Turi, T. G., Thompson, J. F., Sukhova, G. H., Libby, P., and Lee, R. T. (2000) Circulation, 102, 2185-2189.

    Google Scholar 

  118. Galis, Z. S., Sukhova, G. K., Lark, M. W., and Libby, P. (1994) Clin. Invest., 94, 2493-2503.

    Google Scholar 

  119. Kumamoto, M., Nakashima, Y., and Sueishi, K. (1995) Hum. Pathol., 26, 450-456.

    Google Scholar 

  120. Inoue, M., Itoh, H., Ueda, M., Naruko, T., Kojima, A., Komatsu, R., Doi, K., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Yamashita, J., Chun, T. H., Masatsugu, K., Becker, A. E., and Nakao, K. (1998) Circulation, 98, 2108-2116.

    Google Scholar 

  121. Serruys, P. W., and Breeman, A. (1992) Eur. Heart J., 13, 76-88.

    Google Scholar 

  122. Levine, G. N., Chodos, A. P., and Loscalzo, J. (1995) Clin. Cardiol., 18, 693-703.

    Google Scholar 

  123. Nikol, S., Huehns, T., and Höfling, B. (1996) Atherosclerosis, 123, 17-31.

    Google Scholar 

  124. Tkachuk, V., Stepanova, V., Little, P. J., and Bobik, A. (1996) Clin. Exp. Pharmacol. Physiol., 23, 759-765.

    Google Scholar 

  125. Plekhanova, O., Parfyonova, Ye., Bibilashvily, R., Stepanova, V., Erne, P., Bobik, A., and Tkachuk, V. (2000) J. Hypertension, 18, 1065-1069.

    Google Scholar 

  126. Plekhanova, O., Parfyonova, Ye., Bibilashvily, R., Stepanova, V. V., Domogatskii, S., Gulba, D., Agrotis, A., Bobik, A., and Tkachuk, V. A. (2001) Atherosclerosis, in press.

  127. Parfyonova, E. V., Plekhanova, O. S., Kalinina, N. I., Bibilashvily, R. Sh., Bobik, A., and Tkachuk, V. A. (2000) Kardiologiya, 9, 69-77.

    Google Scholar 

  128. Mukhina, S. A., Stepanova, V. V., Matveev, M. Yu., Domogatsky, S. P., and Tkachuk, V. A. (1998) Vopr. Med. Khim., 44, 84-90.

    Google Scholar 

  129. Carmeliet, P., Moons, L., Dewerchin, M., Rosenberg, S., Herbert, J. M., Lupu, F., and Collen, D. (1998) J. Cell. Biol., 140, 233-245.

    Google Scholar 

  130. Carmeliet, P. F. (1995) Baillieres Clin. Haematol., 8, 391-401.

    Google Scholar 

  131. Carmeliet, P., Moons, L., Lijnen, R., Baes, M., Lemaitre, V., Tipping, P., Drew, A., Eeckhout, Y., Shapiro, S., Lupu, F., and Collen, D. (1997) Nat. Genet., 17, 439-444.

    Google Scholar 

  132. Carmeliet, P., Moons, L., Lijnen, R., Janssens, S., Lupu, F., Collen, D., and Gerard, R. D. (1997) Circulation, 96, 3180-3191.

    Google Scholar 

  133. Carmeliet, P., Moons, L., Ploplis, V., Plow, E., and Collen, D. (1997) J. Clin. Invest., 99, 200-208.

    Google Scholar 

  134. Mintz, G. S., Popma, J. J., and Pichard, A. D. (1996) Circulation, 94, 35-43.

    Google Scholar 

  135. Shi, Y., O'Brien, J. E., Jr., Fard, A., and Zalewski, A. (1996) Arterioscler. Thromb. Vasc. Biol., 16, 1298-1305.

    Google Scholar 

  136. Zalewski, A., and Shi, Y. (1997) Arterioscler. Thromb. Vasc. Biol., 13, 417-422.

    Google Scholar 

  137. Plekhanova, O. S., Kalinina, N. I., Volynskaya, E. A., and Parfyonova, E. V. (2000) Byul. Eksp. Biol. Med., 129, 511-514.

    Google Scholar 

  138. Plekhanova, O. S., Solomatina, M. A., Domogatsky, S. P., Naumov, V. G., Tkachuk, V. A., Parfyonova, E. V., and Chazov, E. I. (2001) Ross. Fiziol. Zh. im. I. M. Sechenova, 87, 11-17.

    Google Scholar 

  139. Alekseeva, I. A. (2000) Author's abstract of Candidate's dissertation [in Russian], Russian Cardiology Research Center, Moscow.

    Google Scholar 

  140. Strauss, B. H., Lau, H. K., Bowman, K. A., Sparkes, J., Chisholm, R. J., Garvey, M. B., Fenkell, L. L., Natarajan, M. K., Singh, I., and Teitel, J. (1999) Circulation, 100, 1616-1622.

    Google Scholar 

  141. Lamfers, V. L., Lardenove, J. H., de Vries, M. R., Aalders, M. C., Engelse, M. A., Grimbergen, J. M., van Hinsbergh, V. W., and Quax, P. H. (2001) Gene Ther., 8, 534-541.

    Google Scholar 

  142. Folkman, J. (1987) in Thrombosis and Hemostasis (Verstate, M., Vermylen, J., Lijnen, H., and Arnout, A., eds.) International Society of Thrombosis and Hemostasis and Leuven University Press, Leuven, Belgium, pp. 583-596.

    Google Scholar 

  143. Goldie, I. (1970) Acta Orthop. Scand., 40, 751-764.

    Google Scholar 

  144. Newell, F. W. (1986) Ophthalmology Principles and Concepts, CV Mosby Co., St Louis, MO.

    Google Scholar 

  145. Carmeliet, P. (2000) Nat. Med., 6, 389-395.

    Google Scholar 

  146. Battegay, E. J. (1995) J. Mol. Med., 73, 333-346.

    Google Scholar 

  147. Saksela, O. (1985) Biochim. Biophys. Acta, 823, 35-65.

    Google Scholar 

  148. Murphy, G., Atkinson, S., Ward, R., Gavrilovic, J., and Reynolds, J. J. (1992) Ann. N. Y. Acad. Sci., 667, 1-12.

    Google Scholar 

  149. Mazar, A. P., Henkin, J., and Goklfarb, R. H. (1999) Angiogenesis, 3, 15-32.

    Google Scholar 

  150. Adams, D. O., and Hamilton, T. A. (1992) in Inflammation: Basic Principles and Clinical Correlates (Gallin, J. I., Goldstein, M., and Snyderman, R., eds.) Raven Press, N. Y., pp. 662-667.

    Google Scholar 

  151. Arras, M., Ito, W. D., Scholz, D., Winkler, B., Schaper, J., and Schaper, W. (1998) J. Clin. Invest., 101, 40-50.

    Google Scholar 

  152. Berman, M., Winthrop, D., Ausprunk, D., Rose, J., Langer, R., and Gage, J. (1982) Invest. Ophthalmol. Vis. Sci., 22, 191-199.

    Google Scholar 

  153. Gualandris, A., Conejo, T. L., Giunciuglio, D., Albini, A., Sabini, E., Rusnati, M., Dell'Era, P., and Presta, M. (1997) Vicrovae Res., 53, 254-260.

    Google Scholar 

  154. Graham, C. H., Fitzpatrick, T. E., and McCrae, K. R. (1998) Blood, 91, 3300-3307.

    Google Scholar 

  155. Mandriota, S. J., Seghezzi, G., Vassalli, J. D., Ferrara, N., Wasi, S., Mazzieri, R., Mignatti, P., and Pepper, M. S. (1995) J. Biol. Chem., 270, 9709-9716.

    Google Scholar 

  156. Mignati, P., Mazzieri, R., and Rifkin, D. B. (1991) J. Cell. Biol., 113, 1193-201.

    Google Scholar 

  157. Olofsson, B., Korpelainen, E., Pepper, M. S., Mandriota, S. J., Aase, K., Kumar, V., Gunji, Y., Jeltsch, M. M., Shibuya, M., Alitalo, K., and Eriksson, U. (1998) Proc. Natl. Acad. Sci. USA, 95, 11709-11714.

    Google Scholar 

  158. Pepper, M. S., Ferrara, N., Orci, L., and Montesano, R. (1992) Biochem. Biophys. Res. Commun., 189, 824-831.

    Google Scholar 

  159. Koolwijk, P., van Erck, M. G., de Vree, W. J., Vermeer, M. A., Weich, H. A., Hanemaaijer, R., and van Hinsbergh, V. W. (1996) J. Cell. Biol., 132, 1177-1188.

    Google Scholar 

  160. Odecon, L. E., Sato, Y., and Rifkin, D. B. (1992) J. Cell. Physiol., 150, 258-263.

    Google Scholar 

  161. Lu, H., Mabilat, C., Yeh, P., Guitton, J. D., Li, H., Pouchelet, M., Shoevaert, D., Legrand, Y., Soria, J., and Soria, C. (1996) FEBS Lett., 380, 21-24.

    Google Scholar 

  162. Min, H. Y., Doyle, L. V., Vitt, C. R., Zandonella, C. L., Stratton-Thomas, J. R., Shuman, M. A., and Rosenberg, S. (1996) Cancer Res., 56, 2428-2433.

    Google Scholar 

  163. Lansink, M., Koolwijk, P., van Hinsbergh, V. W., and Kooistra, T. (1998) Blood, 92, 927-938.

    Google Scholar 

  164. Levenson, A. S., Kwaan, H. C., Svoboda, K. M., Weiss, I. M., Sakurai, S., and Jordan, V. C. (1998) Br. J. Cancer, 78, 88-95.

    Google Scholar 

  165. Jain, R. K., Safabakhsh, N., Sckell, A., Chen, Y., Jiang, P., Benjamin, L., Yuan, F., and Keshet, E. (1998) Proc. Natl. Acad. Sci. USA, 95, 10820-10825.

    Google Scholar 

  166. Koolwijk, P., van Erck, M., de Vree, W., Vermeer, M. A., Weich, H. A., Hanemaaijer, R., and van Hinsbergh, V. W. (1996) J. Cell. Biol., 132, 1177-1188.

    Google Scholar 

  167. Kroon, M. E., Koolwijk, P., van Goor, H., Weidle, U. H., Collen, A., van der Pluijm, G., and van Hinsbergh, V. W. (1999) Am. J. Pathol., 154, 1731-1742.

    Google Scholar 

  168. Evans, C. P., Elfman, F., Parangi, S., Conn, M., Cunha, G., and Shuman, M. A. (1997) Cancer Res., 57, 3594-3599.

    Google Scholar 

  169. Asahara, T., Murohara, T., Sulivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., and Isner, J. M. (1997) Science, 275, 964-967.

    Google Scholar 

  170. Tang, H., Kerins, D. M., Hao, Q., Inagami, T., and Vaughan, D. E. (1998) J. Biol. Chem., 273, 18268-18272.

    Google Scholar 

  171. Fibbi, G., Caldini, R., Chevanne, M., Pucci, M., Schiavone, N., Morbidelli, L., Parenti, A., Granger, H. J., del Rosso, M., and Ziche, M. (1998) Lab. Invest., 78, 1109-1119.

    Google Scholar 

  172. Dubois-Stringfellow, N., Jonczyk, A., and Bautch, V. L. (1994) Blood, 33, 3206-3217.

    Google Scholar 

  173. Bajou, K., Noel, A., Gerard, R. D., Masson, V., Brunner, N., Holst-Hansen, C., Skobe, M., Fusenig, N. E., Carmeliet, P., Collen, D., and Foidart, J. M. (1998) Nat. Med., 4, 923-928.

    Google Scholar 

  174. Maehara, Y., Hasuda, S., Abe, T., Oki, E., Kakeji, Y., Ohno, S., and Sugimachi, K. (1998) Clin. Cancer, 4, 2129-2134.

    Google Scholar 

  175. Foekens, J. A., Look, M. P., Peters, H. A., van Putten, W. L., Portengen, H., and Klijn, J. G. (1995) JNCI, 87, 751-756.

    Google Scholar 

  176. Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V., and Kehrl, J. H. (1986) Proc. Natl. Acad. Sci. USA, 83, 4167-4171.

    Google Scholar 

  177. Berse, B., Hunt, J. A., Diegel, R. J., Morganelli, P., Yeo, K., Brown, F., and Fava, R. A. (1999) Clin. Exp. Immunol., 115, 176-182.

    Google Scholar 

  178. Dvorak, H. F., Harvey, V. S., Estrella, P., Brown, L. F., McDonagh, J., and Dvorak, A. M. (1990) J. Cell. Biol., 111, 743-755.

    Google Scholar 

  179. Bacharach, E., Itin, A., and Keshet, E. (1992) Proc. Natl. Acad. Sci. USA, 89, 10686-10690.

    Google Scholar 

  180. Dvorak, H. F., Brown, L. F., Detmar, M., and Dvorak, A. M. (1995) Am. J. Pathol., 146, 1029-1039.

    Google Scholar 

  181. Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E., Moons, L., Dyspersin, G. D., Cleutjens, J. P. M., Shipley, M., Angellilo, A., Levi, M., Nube, O., Baker, A., Keshet, E., Lupu, F., Herbert, J.-M., Smits, J. F. M., Shapiro, S. D., Baes, M., Borgers, M., Collen, D., Daemen, M. J. A. P., and Carmeliet, P. (1999) Nat. Med., 5, 1135-1142.

    Google Scholar 

  182. Li, H., Lu, H., Griscelli, F., Opolon, P., Sun, L. Q., Ragot, T., Legrand, Y., Belin, D., Soria, J., Soria, C., Perricaudet, M., and Yeh, P. (1998) Gene Ther., 1105-1113.

  183. Nakata, S., Ito, K.-I., Fujimori, M., Shingu, K., Kajikawa, S., Adachi, W., Matsuyama, I., Tsuchiya, S., Kuwano, M., and Amano, J. (1998) Int. J. Cancer, 79, 179-186.

    Google Scholar 

  184. Duffy, M. J., Maguire, T. M., McDermott, E. W., and O'Higgins, N. (1999) J. Surg. Oncol., 71, 130-135.

    Google Scholar 

  185. Ugwu, F., van Hoef, B., Bini, A., Collen, D., and Lijnen, H. R. (1998) Biochemistry, 37, 7231-7236.

    Google Scholar 

  186. Guo, Y., Higazi, A. Al-R., Arakelian, A., Sachais, B. S., Cines, D., Goldfarb, R. H., Jones, T. R., Kwaan, H., Mazar, A. P., and Rabbani, S. A. (2000) FASEB J., 14, 1400-1410.

    Google Scholar 

  187. Mishima, K., Mazar, A. P., Gown, A., Skelly, M., Ji, X.-D., Wang, X.-D., Jones, T. R., Cavenee, W. K., and Huang, H.-J. S. (2000) Proc. Natl. Acad. Sci. USA, 97, 8484-8489.

    Google Scholar 

  188. O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. (1994) Cell, 79, 315-328.

    Google Scholar 

  189. Cao, Y., Ji, R. W., Davidson, D., Schaller, J., Marti, D., Sohndel, S., McCance, S. G., O'Reilly, M. S., Llinas, M., and Folkman, J. (1996) J. Biol. Chem., 271, 29461-29467.

    Google Scholar 

  190. Ji, W.-R., Castellino, F. J., Chang, Y., DeFord, M. E., Gray, H., Villarreal, X., Kondri, M. E., Marti, D. H., Llinas, M., Schaller, J., Kramer, R. A., and Trail, P. A. (1998) FASEB J., 12, 1731-1738.

    Google Scholar 

  191. Cao, Y., Chen, A., An, S. S. A., Ji, R. W., Davidson, D., and Llinas, M. (1997) J. Biol. Chem., 272, 22924-22928.

    Google Scholar 

  192. Ji, W.-R., Barrientos, L. G., Llinas, M., Gray, H., Villarreal, X., DeFord, M. E., Castellino, F. J., Kramer, R. A., and Trail, P. (1998) Biochem. Biophys. Res. Commun., 247, 414-419.

    Google Scholar 

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  1. Russian Cardiology Research Center, Ministry of Health of the Russian Federation, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552, Russia

    Ye. V. Parfyonova, O. S. Plekhanova & V. A. Tkachuk

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Parfyonova, Y.V., Plekhanova, O.S. & Tkachuk, V.A. Plasminogen Activators in Vascular Remodeling and Angiogenesis. Biochemistry (Moscow) 67, 119–134 (2002). https://doi.org/10.1023/A:1013964517211

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