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Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

Oncogene volume 18, pages 6158–6162 (1999)Cite this article

Abstract

c-Jun/AP-1 activation has been implicated in various, often opposing cellular responses. For example, although there is considerable evidence that c-Jun activation can be a positive step in the events leading a cell towards apoptosis, there are also many reports stating the opposite: that under certain circumstances c-Jun can inhibit apoptosis and promote proliferation or differentiation instead – and that these responses are important for normal mammalian development. It is clear that the effects of c-Jun on cellular responses depend strongly on the cell type and the context of other regulatory influences that the cell is receiving. This review focuses on recent developments in understanding how activation of JNK and c-Jun contributes to different cellular responses.

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Acknowledgements

The authors thank Jukka Westermark and Catherine Ovitt for critical comments on the manuscript.

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Authors and Affiliations

  1. Haartman Institute, Department of Pathology, University of Helsinki, P.O. Box 21, Finland, FIN-00014

    Sirpa Leppä

  2. European Laboratory for Molecular Biology, Meyerhofstr. 1, Heidelberg, D-69117, Germany

    Dirk Bohmann

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  1. Sirpa Leppä
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Leppä, S., Bohmann, D. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 18, 6158–6162 (1999). https://doi.org/10.1038/sj.onc.1203173

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