Elsevier

Clinical Radiology

Volume 56, Issue 3, March 2001, Pages 216-220
Clinical Radiology

Regular Article
Lobular Carcinoma In situ on Core Biopsy—What is the Clinical Significance?

https://doi.org/10.1053/crad.2000.0615Get rights and content

Abstract

AIM: To retrospectively review the surgical histological findings in all cases where lobular carcinomain situ (LCIS) was identified on percutaneous core biopsy (CB) performed as part of the Cambridge and Huntingdon breast screening programme.

MATERIALS AND METHODS: We retrospectively reviewed all the core biopsies performed in our department for screen detected abnormalities over a 5-year period between 1 April 1994 and 31 March 1999. All patients where LCIS was identified on CB were reviewed. As the significance of LCIS on CB was unclear all went on to surgical excision. We reviewed the clinical and imaging findings, biopsy technique and subsequent surgical histology of each patient.

RESULTS: During the study period 60 769 women were invited for screening, of whom 47 975 attended (attendance rate = 79%). Of these, 2330 (4.9%) were recalled for assessment and 749 (1.6%) underwent CB. A malignant diagnosis was obtained in 311 (42%), 211 invasive and 100 in situ lesions. LCIS was identified on CB in 13 (2%). LCIS was the only lesion identified in seven cases. All seven cases subsequently underwent surgical excision. Surgical histology revealed a single case of LCIS and invasive lobular carcinoma. There were two cases of LCIS and DCIS one with a probable focus of invasive ductal carcinoma. In one case LCIS was identified in association with a radial scar. In three of the seven cases LCIS was the only abnormality on both CB and surgical biopsy.

CONCLUSION: Our series shows that isolated LCIS on CB following mammographic screening is an infrequent finding, and it may be associated with either an invasive cancer or DCIS. It is therefore advisable that when LCIS is identified on CB, surgical excision of the mammographic abnormality should be performed. Decisions on management should be undertaken in a multidisciplinary setting taking into account clinical and imaging findings. O'Driscoll, D.et al.(2001). Clinical Radiology56, 216–220.

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    This presumably represents under-sampling of the carcinoma at the time of core needle biopsy, since carcinomas are rarely found when women with only ADH on excisional biopsy undergo immediate re-excision.34 Whether LCIS is associated with an increased risk of invasive carcinoma or DCIS at immediate re-excision is controversial,35–57 but the overall risk appears lower than that of ADH.36,52,58 Data on the long term risk of invasive carcinoma or DCIS in women diagnosed with either ADH or LCIS on core needle biopsy are limited.

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    All patients were alive and disease free at the last follow-up (100% overall and disease-free survival). Although most reports regarding lobular neoplasia discovered on core needle biopsy of the breast have recommended excisional biopsy for these patients,6–12 nearly all of these studies describe patients who were managed nonoperatively as well. Other reports have suggested criteria for management without excisional biopsy.5,7,14

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Author for correspondence and guarantor of study: D. O'Driscoll, The Department of Diagnostic Imaging, The Ipswich Hospital NHS Trust, Heath Road, Ipswich, Suffolk, IP4 5PD, U.K. Tel: (01473) 712233; Fax: (01473) 703400.

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