Monoclonal antibody TKH2 to the cancer-associated epitope sialosyl Tn shows cross-reactivity with variants of normal colorectal goblet cell mucin
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Sialylated glycoproteins and sialyltransferases in digestive cancers: Mechanisms, diagnostic biomarkers, and therapeutic targets
2024, Critical Reviews in Oncology/HematologySimple sugars to complex disease-mucin-type O-glycans in cancer
2015, Advances in Cancer ResearchCitation Excerpt :While some tumors exhibit elevated ST6GalNAc-I transcript, protein, or activity correlating with STn expression, other tumors, such as colorectal carcinoma, have a reduction in ST6GalNAc-I activity despite robust STn expression, and tissues expressing STn almost always coexpress Tn, which could not be explained by ST6GalNAc-I (Marcos et al., 2011; Vazquez-Martin et al., 2004; Yang et al., 1994). Another Tn-independent mechanism for STn expression derives from studies using alkaline, de-esterifying conditions, which results in STn expression in normal colon (where it is usually absent) but not in other normal tissues such as pancreas (Jass, Allison, & Edgar, 1994; Julien et al., 2012). This suggests that in some tissues acetyl STn may normally conceal STn antigen, and therefore STn may arise in tumors from increased esterase activity.
An O-acetylated sialyl-Tn is involved in ovarian cancer-associated antigenicity
2000, Biochemical and Biophysical Research CommunicationsChapter 11 Human mucosal mucins in diseases
1996, New Comprehensive BiochemistryOvercoming Chemoresistance: Altering pH of Cellular Compartments by Chloroquine and Hydroxychloroquine
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