Sclerosing epithelioid fibrosarcoma: a cytogenetic, immunohistochemical, and ultrastructural study of an unusual histological variant

Cancer Genet Cytogenet. 2000 Jun;119(2):127-31. doi: 10.1016/s0165-4608(99)00225-3.

Abstract

A case of sclerosing epithelioid fibrosarcoma was studied. The tumor cells expressed vimentin, focally epithelial membrane antigen and CD34, contained cisternae of rough endoplasmic reticulum, large Golgi apparatus, many pinocytotic vesicles, and were devoid of basal lamina. Their composite karyotype was 45,Y,t(X;6)(q13;q15), t(6;13)(p11.2;q13),-22¿2/46,Y,t(X;6)(q13;q15),add(13)(p12), add(22)(q13)¿3/44 approximately 46,der(X)t(X;6)(q13;q21),-Y, t(13;14)(q10;q10),-22,add(22)(q13)¿7/46,XY¿8.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antigens, CD34 / analysis
  • Biomarkers, Tumor / analysis
  • Chromosomes, Human, Pair 12 / genetics
  • Clone Cells
  • Fibrosarcoma / chemistry
  • Fibrosarcoma / classification
  • Fibrosarcoma / immunology
  • Fibrosarcoma / pathology*
  • Gene Amplification
  • Humans
  • Karyotyping
  • Ki-67 Antigen / analysis
  • Leg
  • Male
  • Middle Aged
  • Neoplasm Proteins / analysis
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / immunology
  • Soft Tissue Neoplasms / pathology*
  • Trans-Activators / genetics

Substances

  • Antigens, CD34
  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Neoplasm Proteins
  • Trans-Activators